This title appears in the Scientific Report :
2023
Please use the identifier:
http://dx.doi.org/10.1002/mds.29389 in citations.
Please use the identifier: http://dx.doi.org/10.34734/FZJ-2023-02214 in citations.
Evaluation of a Structured Screening Assessment to Detect Isolated Rapid Eye Movement Sleep Behavior Disorder
Evaluation of a Structured Screening Assessment to Detect Isolated Rapid Eye Movement Sleep Behavior Disorder
ABSTRACT: Background: Isolated rapid eye movement(REM) sleep behavior disorder (iRBD) cohorts have providedinsights into the earliest neurodegenerative processes inα-synucleinopathies. Even though polysomnography (PSG)remains the gold standard for diagnosis, an accuratequestionnaire-based algorithm...
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Personal Name(s): | Seger, Aline (Corresponding author) |
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Ophey, Anja / Heitzmann, Wiebke / Doppler, Christopher E. J. / Lindner, Marie-Sophie / Brune, Corinna / Kickartz, Johanna / Dafsari, Haidar S. / Oertel, Wolfgang H. / Fink, Gereon R. / Jost, Stefanie T. / Sommerauer, Michael (Corresponding author) | |
Contributing Institute: |
Kognitive Neurowissenschaften; INM-3 |
Published in: | Movement disorders, 38 (2023) 6, S. 990-999 |
Imprint: |
New York, NY
Wiley
2023
|
DOI: |
10.1002/mds.29389 |
DOI: |
10.34734/FZJ-2023-02214 |
Document Type: |
Journal Article |
Research Program: |
SFB 1451: Schlüsselmechanismen normaler und krankheitsbedingt gestörter motorischer Kontrolle Brain Dysfunction and Plasticity |
Link: |
OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.34734/FZJ-2023-02214 in citations.
ABSTRACT: Background: Isolated rapid eye movement(REM) sleep behavior disorder (iRBD) cohorts have providedinsights into the earliest neurodegenerative processes inα-synucleinopathies. Even though polysomnography (PSG)remains the gold standard for diagnosis, an accuratequestionnaire-based algorithm to identify eligible subjectscould facilitate efficient recruitment in research.Objective: This study aimed to optimize the identificationof subjects with iRBD from the general population.Methods: Between June 2020 and July 2021, we placednewspaper advertisements, including the single-questionscreen for RBD (RBD1Q). Participants’ evaluationsincluded a structured telephone screening consisting ofthe RBD screening questionnaire (RBDSQ) and additionalsleep-related questionnaires. We examined anamnesticinformation predicting PSG-proven iRBD using logisticregressions and receiver operating characteristic curves.Results: Five hundred forty-three participants answeredthe advertisements, and 185 subjects fulfilling inclusionand exclusion criteria were screened. Of these,124 received PSG after expert selection, and 78 (62.9%)were diagnosed with iRBD. Selected items of theRBDSQ, the Pittsburgh Sleep Quality Index, the STOPBangquestionnaire, and age predicted iRBD with highaccuracy in a multiple logistic regression model (areaunder the curve >80%). When comparing the algorithmto the sleep expert decision, 77 instead of 124 polysomnographies(62.1%) would have been carried out,and 63 (80.8%) iRBD patients would have been identified;32 of 46 (69.6%) unnecessary PSG examinationscould have been avoided.Conclusions: Our proposed algorithm displayed highdiagnostic accuracy for PSG-proven iRBD costeffectivelyand may be a convenient tool for research andclinical settings. External validation sets are warranted toprove reliability. © 2023 The Authors. Movement Disorderspublished by Wiley Periodicals LLC on behalf ofInternational Parkinson and Movement Disorder Society.Key Words: general population; Parkinson’s disease;prediction; questionnaire; rapid eye movement sleepbehavior disorder |