This title appears in the Scientific Report :
2023
Please use the identifier:
http://dx.doi.org/10.1016/j.parkreldis.2023.105478 in citations.
Please use the identifier: http://dx.doi.org/10.34734/FZJ-2023-02378 in citations.
Low beta-band suppression as a tool for DBS contact selection for akinetic-rigid symptoms in Parkinson's disease
Low beta-band suppression as a tool for DBS contact selection for akinetic-rigid symptoms in Parkinson's disease
AbstractBackground: Suppression of pathologically altered activity in the beta-band has previously been suggested as a biomarker for feedback-based neurostimulation in subthalamic deep brain stimulation (STN-DBS) for Parkinson's Disease (PD).Objective: To assess the utility of beta-band suppres...
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Personal Name(s): | Strelow, Joshua N. (Corresponding author) |
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Dembek, Till A. / Baldermann, Juan C. / Andrade, Pablo / Fink, Gereon R. / Visser-Vandewalle, Veerle / Barbe, Michael T. | |
Contributing Institute: |
Kognitive Neurowissenschaften; INM-3 |
Published in: | Parkinsonism & related disorders, 112 (2023) S. 105478 - |
Imprint: |
Amsterdam [u.a.]
Elsevier Science
2023
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DOI: |
10.1016/j.parkreldis.2023.105478 |
DOI: |
10.34734/FZJ-2023-02378 |
Document Type: |
Journal Article |
Research Program: |
SFB 1451: Schlüsselmechanismen normaler und krankheitsbedingt gestörter motorischer Kontrolle Multilevel Brain Organization and Variability |
Link: |
Restricted OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.34734/FZJ-2023-02378 in citations.
AbstractBackground: Suppression of pathologically altered activity in the beta-band has previously been suggested as a biomarker for feedback-based neurostimulation in subthalamic deep brain stimulation (STN-DBS) for Parkinson's Disease (PD).Objective: To assess the utility of beta-band suppression as a tool for contact selection in STN-DBS for PD.Methods: A sample of seven PD patients (13 hemispheres) with newly implanted directional DBS leads of the STN were recorded during a standardized monopolar contact review (MPR). Recordings were received from contact pairs adjacent to the stimulation contact. The degree of beta-band suppression for each investigated contact was then correlated to the respective clinical results. Additionally, we have implemented a cumulative ROC analysis, to test the predictive value of beta-band suppression on the clinical efficacy of the respective contacts.Results: Stimulation ramping led to frequency-specific changes in the beta-band, while lower frequencies remained unaffected. Most importantly, our results showed that the degree of low beta-band suppression from baseline activity (stimulation off) served as a predictor for clinical efficacy of the respective stimulation contact. In contrast suppression of high beta-band activity yielded no predictive power.Conclusion: The degree of low beta-band suppression can serve as a time-saving, objective tool for contact selection in STN-DBS.Keywords: DBS programming; Deep brain stimulation (DBS); Local field potential (LFP); Nucleus subthalamicus (STN). |