This title appears in the Scientific Report :
2023
Please use the identifier:
http://dx.doi.org/10.7554/eLife.83843 in citations.
Please use the identifier: http://dx.doi.org/10.34734/FZJ-2023-02934 in citations.
Cerebral chemoarchitecture shares organizational traits with brain structure and function
Cerebral chemoarchitecture shares organizational traits with brain structure and function
Chemoarchitecture, the heterogeneous distribution of neurotransmitter transporter and receptor molecules, is a relevant component of structure–function relationships in the human brain. Here, we studied the organization of the receptome, a measure of interareal chemoarchitectural similarity, derived...
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Personal Name(s): | Hänisch, Benjamin |
---|---|
Hansen, Justine Y / Bernhardt, Boris C / Eickhoff, Simon B / Dukart, Juergen / Misic, Bratislav / Valk, Sofie Louise (Corresponding author) | |
Contributing Institute: |
Gehirn & Verhalten; INM-7 |
Published in: | eLife, 12 (2023) S. e83843 |
Imprint: |
Cambridge
eLife Sciences Publications
2023
|
DOI: |
10.7554/eLife.83843 |
DOI: |
10.34734/FZJ-2023-02934 |
Document Type: |
Journal Article |
Research Program: |
Multilevel Brain Organization and Variability |
Link: |
OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.34734/FZJ-2023-02934 in citations.
Chemoarchitecture, the heterogeneous distribution of neurotransmitter transporter and receptor molecules, is a relevant component of structure–function relationships in the human brain. Here, we studied the organization of the receptome, a measure of interareal chemoarchitectural similarity, derived from positron-emission tomography imaging studies of 19 different neurotransmitter transporters and receptors. Nonlinear dimensionality reduction revealed three main spatial gradients of cortical chemoarchitectural similarity – a centro-temporal gradient, an occipito-frontal gradient, and a temporo-occipital gradient. In subcortical nuclei, chemoarchitectural similarity distinguished functional communities and delineated a striato-thalamic axis. Overall, the cortical receptome shared key organizational traits with functional and structural brain anatomy, with node-level correspondence to functional, microstructural, and diffusion MRI-based measures decreasing along a primary-to-transmodal axis. Relative to primary and paralimbic regions, unimodal and heteromodal regions showed higher receptomic diversification, possibly supporting functional flexibility. |