This title appears in the Scientific Report :
2023
Please use the identifier:
http://dx.doi.org/10.1101/2023.06.14.544966 in citations.
Please use the identifier: http://dx.doi.org/10.34734/FZJ-2023-02947 in citations.
Neural manifolds in V1 change with top-down signals from V4 targeting the foveal region
Neural manifolds in V1 change with top-down signals from V4 targeting the foveal region
High-dimensional brain activity is often organised into lower-dimensional neural manifolds. However, the neural manifolds of the visual cortex remain understudied. Here, we study large-scale multielectrode electrophysiological recordings of macaque (Macaca mulatta) areas V1, V4 and DP with a high sp...
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Personal Name(s): | Morales-Gregorio, Aitor (Corresponding author) |
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Kurth, Anno C. / Ito, Junji / Kleinjohann, Alexander / Barthélemy, Frédéric V. / Brochier, Thomas / Grün, Sonja / van Albada, Sacha J. | |
Contributing Institute: |
Computational and Systems Neuroscience; INM-6 Jara-Institut Brain structure-function relationships; INM-10 Computational and Systems Neuroscience; IAS-6 |
Imprint: |
bioRxiv
2023
|
DOI: |
10.1101/2023.06.14.544966 |
DOI: |
10.34734/FZJ-2023-02947 |
Document Type: |
Preprint |
Research Program: |
Heterogenität von Zytoarchitektur, Chemoarchitektur und Konnektivität in einem großskaligen Computermodell der menschlichen Großhirnrinde GRK 2416: MultiSenses-MultiScales: Neue Ansätze zur Aufklärung neuronaler multisensorischer Integration Human Brain Project Specific Grant Agreement 3 Neuroscientific Foundations |
Link: |
OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.34734/FZJ-2023-02947 in citations.
High-dimensional brain activity is often organised into lower-dimensional neural manifolds. However, the neural manifolds of the visual cortex remain understudied. Here, we study large-scale multielectrode electrophysiological recordings of macaque (Macaca mulatta) areas V1, V4 and DP with a high spatio-temporal resolution. We find, for the first time, that the population activity of V1 contains two separate neural manifolds, which correlate strongly with eye closure (eyes open/closed) and have distinct dimensionalities. Moreover, we find strong top-down signals from V4 to V1, particularly to the foveal region of V1, which are significantly stronger during the eyes-open periods, a previously unknown effect. Finally, in silico simulations of a balanced spiking neuron network qualitatively reproduce the experimental findings. Taken together, our analyses and simulations suggest that top-down signals modulate the population activity of V1, causing two distinct neural manifolds. We postulate that the top-down modulation during the eyes-open periods prepares V1 for fast and efficient visual responses, resulting in a type of visual stand-by mode. |