This title appears in the Scientific Report :
2023
Please use the identifier:
http://dx.doi.org/10.1111/ene.16040 in citations.
Please use the identifier: http://dx.doi.org/10.34734/FZJ-2023-04884 in citations.
Botulism after intragastric botulinum toxin injections for weight reduction
Botulism after intragastric botulinum toxin injections for weight reduction
Although-considering the risk-benefit ratio-botulinum neurotoxin A (BoNT/A) is unequivocally recommended to treat severe neurological diseases such as dystonia, this has not yet been determined for its endoscopic intragastric injection aimed at weight reduction in obesity. However, severe adverse ef...
Saved in:
Personal Name(s): | Hennen, Christina (First author) |
---|---|
Demir, Seda / Dafsari, Haidar Salimi / Wunderlich, Gilbert / Böll, Boris / Hüser, Christoph / Barbe, Michael Thomas / Fink, Gereon Rudolf / Rueger, Maria Adele (Corresponding author) | |
Contributing Institute: |
Kognitive Neurowissenschaften; INM-3 |
Published in: | European journal of neurology, 30 (2023) 12, S. 3979 - 3981 |
Imprint: |
Oxford [u.a.]
Wiley-Blackwell
2023
|
DOI: |
10.1111/ene.16040 |
DOI: |
10.34734/FZJ-2023-04884 |
Document Type: |
Journal Article |
Research Program: |
Multilevel Brain Organization and Variability |
Link: |
Get full text Published on 2023-08-16. Available in OpenAccess from 2024-08-16. |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.34734/FZJ-2023-04884 in citations.
Although-considering the risk-benefit ratio-botulinum neurotoxin A (BoNT/A) is unequivocally recommended to treat severe neurological diseases such as dystonia, this has not yet been determined for its endoscopic intragastric injection aimed at weight reduction in obesity. However, severe adverse effects of intragastric BoNT/A had not yet been reported, prompting some European countries to endorse its (off-label) use and treat patients transnationally. We here present three cases of botulism after intragastric BoNT/A injections for obesity treatment in a Turkish hospital. Patients presented with cranial nerve affection, bulbar symptoms, and descending paresis, and benefited from treatment with BoNT antitoxin and pyridostigmine. We assume that iatrogenic botulism was induced by overdosing in combination with toxin spread via the highly vascularized gastric tissue. Of note, within a few weeks, more than 80 cases of iatrogenic botulism were reported across Europe after identical intragastric BoNT/A injections. These cases demonstrate the risks of BoNT/A injections if they are not applied within the limits of evidence-based medicine. There is a need for international guidelines to define the indication and a safe dosing scheme, especially in the context of medical tourism.Keywords: botulinum toxins; botulism; medical tourism; obesity. |