This title appears in the Scientific Report :
2023
Please use the identifier:
http://dx.doi.org/10.34734/FZJ-2023-05202 in citations.
Please use the identifier: http://dx.doi.org/10.1016/j.bpsc.2023.06.002 in citations.
Hippocampus-Centered Network Is Associated With Positive Symptom Alleviation in Patients With First-Episode Psychosis
Hippocampus-Centered Network Is Associated With Positive Symptom Alleviation in Patients With First-Episode Psychosis
BackgroundPrevious functional magnetic resonance imaging studies have reported widespread brain functional connectivity alterations in patients with psychosis. These studies have mostly used either resting-state or simple-task paradigms, thereby compromising experimental control or ecological validi...
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Personal Name(s): | Alho, Jussi (Corresponding author) |
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Lahnakoski, Juha M. / Panula, Jonatan M. / Rikandi, Eva / Mäntylä, Teemu / Lindgren, Maija / Kieseppä, Tuula / Suvisaari, Jaana / Sams, Mikko / Raij, Tuukka T. (Corresponding author) | |
Contributing Institute: |
Gehirn & Verhalten; INM-7 |
Published in: | Biological psychiatry / Cognitive neuroscience and neuroimaging, 8 (2023) 12, S. 1197 - 1206 |
Imprint: |
Amsterdam [u.a.]
Elsevier Inc.
2023
|
DOI: |
10.34734/FZJ-2023-05202 |
DOI: |
10.1016/j.bpsc.2023.06.002 |
Document Type: |
Journal Article |
Research Program: |
Brain Dysfunction and Plasticity |
Link: |
Get full text OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.1016/j.bpsc.2023.06.002 in citations.
BackgroundPrevious functional magnetic resonance imaging studies have reported widespread brain functional connectivity alterations in patients with psychosis. These studies have mostly used either resting-state or simple-task paradigms, thereby compromising experimental control or ecological validity, respectively. Additionally, in a conventional functional magnetic resonance imaging intrasubject functional connectivity analysis, it is difficult to identify which connections relate to extrinsic (stimulus-induced) and which connections relate to intrinsic (non–stimulus-related) neural processes.MethodsTo mitigate these limitations, we used intersubject functional connectivity (ISFC) to analyze longitudinal functional magnetic resonance imaging data collected while 36 individuals with first-episode psychosis (FEP) and 29 age- and sex-matched population control participants watched scenes from the fantasy movie Alice in Wonderland at baseline and again at 1-year follow-up. Furthermore, to allow unconfounded comparison and to overcome possible circularity of ISFC, we introduced a novel approach wherein ISFC in both the FEP and population control groups was calculated with respect to an independent group of participants (not included in the analyses).ResultsUsing this independent-reference ISFC approach, we found an interaction effect wherein the independent-reference ISFC in individuals with FEP, but not in the control group participants, was significantly stronger at baseline than at follow-up in a network centered in the hippocampus and involving thalamic, striatal, and cortical regions, such as the orbitofrontal cortex. Alleviation of positive symptoms, particularly delusions, from baseline to follow-up was correlated with decreased network connectivity in patients with FEP.ConclusionsThese findings link deviation of naturalistic information processing in the hippocampus-centered network to positive symptoms. |