This title appears in the Scientific Report :
2023
Please use the identifier:
http://dx.doi.org/10.34734/FZJ-2023-05665 in citations.
Strain- and process engineering for polyketides production with Pseudomonas taiwanensis VLB120 in two-phase cultivations
Strain- and process engineering for polyketides production with Pseudomonas taiwanensis VLB120 in two-phase cultivations
Polyketides are a highly diverse group of secondary metabolites with great potential for lead compounds for applications in multiple industries. Biotechnological hosts are frequently used for their heterologous production. For polyketide synthesis, identical precursors are assembled to complex compo...
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Personal Name(s): | Schwanemann, Tobias (Corresponding author) |
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Contributing Institute: |
Biotechnologie; IBG-1 |
Imprint: |
Jülich
Forschungszentrum Jülich GmbH Zentralbibliothek, Verlag
2023
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Physical Description: |
230 |
Dissertation Note: |
Dissertation, Univ. Düsseldorf, 2023 |
ISBN: |
978-3-95806-726-4 |
DOI: |
10.34734/FZJ-2023-05665 |
Document Type: |
Book Dissertation / PhD Thesis |
Research Program: |
Utilization of renewable carbon and energy sources and engineering of ecosystem functions |
Series Title: |
Schriften des Forschungszentrums Jülich Reihe Schlüsseltechnologien / Key Technologies
276 |
Link: |
OpenAccess |
Publikationsportal JuSER |
Polyketides are a highly diverse group of secondary metabolites with great potential for lead compounds for applications in multiple industries. Biotechnological hosts are frequently used for their heterologous production. For polyketide synthesis, identical precursors are assembled to complex compounds with highly different properties while using the same cellular resources. Consequently, the choice of polyketide synthase (PKS) determines the final product and the interchangeable nature of PKS allows the production of various compounds by minimal modifications of the host organism. In particular, PKS III represent an interesting group of catalysts due to their simplicity compared to other PKS. In this work, an alternative bacterial production host, Pseudomonas taiwanensis VLB120, was developed for the production of various polyketide products in two-phase cultivations for in situ product removal. |