This title appears in the Scientific Report :
2024
Please use the identifier:
http://dx.doi.org/10.34734/FZJ-2024-00551 in citations.
Please use the identifier: http://dx.doi.org/10.1016/j.ijchp.2023.100432 in citations.
Volume of the Dentate Gyrus/CA4 Hippocampal subfield mediates the interplay between sleep quality and depressive symptoms
Volume of the Dentate Gyrus/CA4 Hippocampal subfield mediates the interplay between sleep quality and depressive symptoms
BackgroundEmerging evidence increasingly suggests that poor sleep quality is associated with depressive symptoms. The hippocampus might play a crucial role in the interplay between sleep disturbance and depressive symptomatology, e.g., hippocampal atrophy is typically seen in both insomnia disorder...
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Personal Name(s): | Wang, Yulin |
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Tian, Yun / Long, Zhiliang / Dong, Debo / He, Qinghua / Qiu, Jiang / Feng, Tingyong / Chen, Hong / Tahmasian, Masoud / Lei, Xu (Corresponding author) | |
Contributing Institute: |
Gehirn & Verhalten; INM-7 |
Published in: | International journal of clinical and health psychology, 24 (2024) 1, S. 100432 - |
Imprint: |
Barcelona
Elsevier
2024
|
DOI: |
10.34734/FZJ-2024-00551 |
DOI: |
10.1016/j.ijchp.2023.100432 |
Document Type: |
Journal Article |
Research Program: |
Brain Dysfunction and Plasticity |
Link: |
OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.1016/j.ijchp.2023.100432 in citations.
BackgroundEmerging evidence increasingly suggests that poor sleep quality is associated with depressive symptoms. The hippocampus might play a crucial role in the interplay between sleep disturbance and depressive symptomatology, e.g., hippocampal atrophy is typically seen in both insomnia disorder and depression. Thus, examining the role of hippocampal volume in the interplay between poor sleep quality and depressive symptoms in large healthy populations is vital.MethodsWe investigated the association between self-reported sleep quality, depressive symptoms, and hippocampal total and subfields’ volumes in 1603 healthy young adults from the Behavioral Brain Research Project. Mediation analysis explored the mediating role of hippocampal volumes between sleep quality and depressive symptoms.ResultsSelf-reported sleep quality and depressive symptoms were positively correlated. In addition, it negatively related to three hippocampal subfields but not total hippocampal volume. In particular, hippocampal subfield DG and CA4 volumes mediated the interrelationship between poor sleep quality and depressive symptoms.ConclusionsOur findings improved the current understanding of the relationship between sleep disturbance, depressive symptomatology, and hippocampal subfields in healthy populations. Considering the crucial role of DG in hippocampal neurogenesis, our results suggest that poor sleep quality may contribute to depression through a reduction of DG volume leading to impaired neurogenesis which is crucial for the regulation of mood. |