This title appears in the Scientific Report :
2024
Please use the identifier:
http://dx.doi.org/10.1523/JNEUROSCI.0856-23.2024 in citations.
Please use the identifier: http://dx.doi.org/10.34734/FZJ-2024-01503 in citations.
Co-representation of functional brain networks is shaped by cortical myeloarchitecture and reveals individual behavioral ability
Co-representation of functional brain networks is shaped by cortical myeloarchitecture and reveals individual behavioral ability
Large-scale functional networks are spatially distributed in the human brain. Despite recent progress in differentiating the functional roles of specific brain networks, how the brain navigates the spatial coordination among them and the biological relevance of this coordination is still not fully u...
Saved in:
Personal Name(s): | Chu, Congying |
---|---|
Li, Wen / Shi, Weiyang / Wang, Haiyan / Wang, Jiaojian / Liu, Yong / Liu, Bing / Elmenhorst, David / Eickhoff, Simon B. / Fan, Lingzhong / Jiang, Tianzi (Corresponding author) | |
Contributing Institute: |
Molekulare Organisation des Gehirns; INM-2 Gehirn & Verhalten; INM-7 |
Published in: | The journal of neuroscience, 44 (2024) 3, S. e0856232024 - |
Imprint: |
Washington, DC
Soc.
2024
|
DOI: |
10.1523/JNEUROSCI.0856-23.2024 |
DOI: |
10.34734/FZJ-2024-01503 |
Document Type: |
Journal Article |
Research Program: |
Brain Dysfunction and Plasticity Multilevel Brain Organization and Variability |
Link: |
Published on 2024-03-27. Available in OpenAccess from 2024-09-27. |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.34734/FZJ-2024-01503 in citations.
Large-scale functional networks are spatially distributed in the human brain. Despite recent progress in differentiating the functional roles of specific brain networks, how the brain navigates the spatial coordination among them and the biological relevance of this coordination is still not fully understood. Capitalizing on canonical individualized networks derived from functional MRI data, we proposed a new concept, i.e., co-representation of functional brain networks, to delineate the spatial coordination among them. To further quantify the co-representation pattern, we defined two indexes, i.e., the co-representation specificity (CoRS) and intensity (CoRI), for separately measuring the extent of specific and average expression of functional networks at each brain location by using the data from both sexes. We found that the identified pattern of co-representation was anchored by cortical regions with three types of cytoarchitectural classes along a sensory-fugal axis, including, at the first end, primary (idiotypic) regions showing high CoRS, at the second end, heteromodal regions showing low CoRS and high CoRI, at the third end, paralimbic regions showing low CoRI. Importantly, we demonstrated the critical role of myeloarchitecture in sculpting the spatial distribution of co-representation by assessing the association with the myelin-related neuroanatomical and transcriptomic profiles. Furthermore, the significance of manifesting the co-representation was revealed in its prediction of individual behavioral ability. Our findings indicated that the spatial coordination among functional networks was built upon an anatomically configured blueprint to facilitate neural information processing, while advancing our understanding of the topographical organization of the brain by emphasizing the assembly of functional networks. |