Comparison of histological delineation of the entorhinal, perirhinal, ectorhinal, and parahippocampal cortices by different neuroanatomy laboratories
Comparison of histological delineation of the entorhinal, perirhinal, ectorhinal, and parahippocampal cortices by different neuroanatomy laboratories
The medial temporal lobe (MTL) cortex, located adjacent to the hippocampus,is crucial for memory and a hotspot of neurodegenerative processes (e.g.,accumulation of tau tangles or TDP-43). Importantly, theMTLcortex comprises severalsubregions with distinct functional, cytoarchitectonic, and macro-ana...
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Personal Name(s): | Baumeister, Hannah |
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Wuestefeld, Anika (Corresponding author) / Adams, Jenna N. / Bakker, Arnold / Daugherty, Ana M. / de Flores, Robin / Hodgetts, Carl J / La Joie, Renaud / Mazloum-Farzaghi, Negar / Olsen, Rosanna K / Puliyadi, Vyash / Stark, Craig E. L. / Tran, Tammy T / Wang, Lei / Yushkevich, Paul A. / Amunts, Katrin / Augustinack, Jean / Ding, Song-Lin / Insausti, Ricardo / Kedo, Olga / Berron, David / Wisse, Laura EM | |
Contributing Institute: |
Strukturelle und funktionelle Organisation des Gehirns; INM-1 |
Imprint: |
2023
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Conference: | Alzheimer's Imaging Consortium, Amsterdam (Netherlands), 2023-07-15 - 2023-07-15 |
Document Type: |
Abstract |
Research Program: |
Multilevel Brain Organization and Variability |
Publikationsportal JuSER |
The medial temporal lobe (MTL) cortex, located adjacent to the hippocampus,is crucial for memory and a hotspot of neurodegenerative processes (e.g.,accumulation of tau tangles or TDP-43). Importantly, theMTLcortex comprises severalsubregions with distinct functional, cytoarchitectonic, and macro-anatomical features(Fig. 1). In vivo imaging studies measuring atrophy or aggregates of pathologies in thesesubregions rely on various segmentation protocols. Comparability of these imagingstudies is limited as segmentation protocols differ, which results from different macroanatomicalparcellations and cytoarchitectonic definitions of MTL subregions. Thus,it must be clarified to which extent definitions of MTL subregions overlap betweenneuroanatomists, to establish a harmonized MTL magnetic resonance imaging (MRI)segmentation protocol. We give an overview of cytoarchitectonic definitions of MTLcortex subregions provided by four neuroanatomists from independent laboratories. |