This title appears in the Scientific Report :
2024
Please use the identifier:
http://dx.doi.org/10.1016/j.neuroimage.2024.120641 in citations.
Please use the identifier: http://dx.doi.org/10.34734/FZJ-2024-03393 in citations.
Common neural dysfunction of economic decision-making across psychiatric conditions
Common neural dysfunction of economic decision-making across psychiatric conditions
Adaptive decision-making, which is often impaired in various psychiatric conditions, is essential for well-being. Recent evidence has indicated that decision-making capacity in multiple tasks could be accounted for by latent dimensions, enlightening the question of whether there is a common disrupti...
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Personal Name(s): | Feng, Chunliang (Corresponding author) |
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Liu, Qingxia / Huang, Chuangbing / Li, Ting / Wang, Li / Liu, Feilong / Eickhoff, Simon B. / Qu, Chen (Corresponding author) | |
Contributing Institute: |
Gehirn & Verhalten; INM-7 |
Published in: | NeuroImage, 294 (2024) S. 120641 - |
Imprint: |
Orlando, Fla.
Academic Press
2024
|
DOI: |
10.1016/j.neuroimage.2024.120641 |
DOI: |
10.34734/FZJ-2024-03393 |
Document Type: |
Journal Article |
Research Program: |
Brain Dysfunction and Plasticity |
Link: |
OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.34734/FZJ-2024-03393 in citations.
Adaptive decision-making, which is often impaired in various psychiatric conditions, is essential for well-being. Recent evidence has indicated that decision-making capacity in multiple tasks could be accounted for by latent dimensions, enlightening the question of whether there is a common disruption of brain networks in economic decision-making across psychiatric conditions. Here, we addressed the issue by combining activation/lesion network mapping analyses with a transdiagnostic brain imaging meta-analysis. Our findings indicate that there were transdiagnostic alterations in the thalamus and ventral striatum during the decision or outcome stage of decision-making. The identified regions represent key nodes in a large-scale network, which is composed of multiple heterogeneous brain regions and plays a causal role in motivational functioning. The findings suggest that disturbances in the network associated with emotion- and reward-related processing play a key role in dysfunctions of decision‐making observed in various psychiatric conditions. This study provides the first meta-analytic evidence of common neural alterations linked to deficits in economic decision-making. |