This title appears in the Scientific Report :
2008
Please use the identifier:
http://dx.doi.org/10.1002/pssa.200879713 in citations.
Penicillin detection with nanocrystalline-diamond field-effect sensor
Penicillin detection with nanocrystalline-diamond field-effect sensor
Nanocrystalline-diamond (NCD) films have been utilised for the detection of penicillin G for the first time. The developed penicillin-sensitive biosensor consists of a field-effect capacitive electrolyte-diamond-insulator-semiconductor (EDIS) structure with an immobilised enzyme layer that covers th...
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Personal Name(s): | Abouzar, M. H. |
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Poghossian, A. / Razavi, A. / Besmehn, A. / Bijnens, N. / Williams, O. A. / Haenen, K. / Wagner, P. / Schöning, M. J. | |
Contributing Institute: |
Zentralabteilung für Chemische Analysen; ZCH Institut für Bio- und Nanosysteme - Bioelektronik; IBN-2 |
Published in: | Physica status solidi / A, 205 (2008) S. 2141 - 2145 |
Imprint: |
Weinheim
Wiley-VCH
2008
|
Physical Description: |
2141 - 2145 |
DOI: |
10.1002/pssa.200879713 |
Document Type: |
Journal Article |
Research Program: |
Grundlagen für zukünftige Informationstechnologien |
Series Title: |
Physica Status Solidi A
205 |
Subject (ZB): | |
Publikationsportal JuSER |
Nanocrystalline-diamond (NCD) films have been utilised for the detection of penicillin G for the first time. The developed penicillin-sensitive biosensor consists of a field-effect capacitive electrolyte-diamond-insulator-semiconductor (EDIS) structure with an immobilised enzyme layer that covers the gate region of the sensor. Undoped NCD thin films of about 100 nm thickness were grown on a p-Si-SiO2 (50 nm thermally grown SiO2) structure by microwave plasma-enhanced chemical vapour deposition. The enzyme penicillinase has been adsorptively immobilised directly onto the O-terminated NCD surface. The EDIS biosensors have been characterised in buffer solutions with different content of penicillin G by means of capacitance-voltage and constant-capacitance method. The developed penicillin biosensor possesses a low detection limit of 5 mu M and a high sensitivity of 6070 mV/decade in a wide linear range of 0.005-2.5 mM penicillin G concentration. (C) 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |