This title appears in the Scientific Report :
2008
Please use the identifier:
http://dx.doi.org/10.1134/S1027451008060128 in citations.
Comparative Analysis of Sensory Rhodopsin II Structures in Complex with a Transducer and without It
Comparative Analysis of Sensory Rhodopsin II Structures in Complex with a Transducer and without It
Sensory rhodopsin II (NpSRII) is a heptahelical transmembrane protein containing the retinal chromophore. In complex with another membrane protein, i.e., NpHtrII transducer, NpSRII transmits a signal into a cell, initiating negative phototaxis of Natronobacterium pharaonis. In the absence of a trans...
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Personal Name(s): | Reshetnyak, A.B. |
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Borshchevskii, V.I. / Klare, J. / Moiseeva, E.S. / Engelhardt, M. / Büldt, G. / Gordeliy, V. I. | |
Contributing Institute: |
Molekulare Biophysik; INB-2 |
Published in: | Journal of Surface Investigation. X-ray, Synchrotron and Neutron Techniques, 2 (2008) S. 894 - 899 |
Imprint: |
Moscow
MAIK Nauka/Interperiodics Publ.
2008
|
Physical Description: |
894 - 899 |
DOI: |
10.1134/S1027451008060128 |
Document Type: |
Journal Article |
Research Program: |
Funktion und Dysfunktion des Nervensystems |
Series Title: |
Journal of Surface Investigation : X-ray, Synchrotron and Neutron Techniques
2 |
Subject (ZB): | |
Publikationsportal JuSER |
Sensory rhodopsin II (NpSRII) is a heptahelical transmembrane protein containing the retinal chromophore. In complex with another membrane protein, i.e., NpHtrII transducer, NpSRII transmits a signal into a cell, initiating negative phototaxis of Natronobacterium pharaonis. In the absence of a transducer, rhodopsin II can work as a proton pump similar to bacteriorhodopsin. The main objective of this study is to comparatively analyze receptor structures in complex with the transducer and without it to understand the mechanism of the protein switching function. Diffraction data for sensory rhodopsin II crystals grown in the lipidic cubic phase were obtained at the synchrotron x-ray source. In this paper, we present a new NpSRII structure with a resolution of 2.1 angstrom and the results of a comparative analysis of the obtained NpSRII structure with our previously published data on the NpSRII/NpHtrII complex structure and with two NpSRII structures without a transducer, previously published in the literature. |