This title appears in the Scientific Report :
2012
Please use the identifier:
http://dx.doi.org/10.1002/smll.201200465 in citations.
Control of Cell Adhesion and Neurite Outgrowth by Patterned Gold Nanoparticles with Tunable Attractive or Repulsive Surface Properties
Control of Cell Adhesion and Neurite Outgrowth by Patterned Gold Nanoparticles with Tunable Attractive or Repulsive Surface Properties
Guiding of neuronal cells on surfaces is required for the investigation of fundamental aspects of neurobiology, for tissue engineering, and for numerous bioelectronic applications. A modular method to establish nanostructured chemical templates for local deposition of gold nanoparticles is presented...
Saved in:
Personal Name(s): | Gilles, S. |
---|---|
Winter, S. / Michael, K. E. / Meffert, S. / Li, P. / Greben, K. / Simon, U. / Offenhäusser, A. / Mayer, D. | |
Contributing Institute: |
Bioelektronik; ICS-8 JARA-FIT; JARA-FIT Bioelektronik; PGI-8 |
Published in: | Small, 8 (2012) S. 3357 - 3367 |
Imprint: |
Weinheim
Wiley-VCH Verl.
2012
|
Physical Description: |
3357 - 3367 |
PubMed ID: |
22826008 |
DOI: |
10.1002/smll.201200465 |
Document Type: |
Journal Article |
Research Program: |
BioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung Grundlagen für zukünftige Informationstechnologien |
Series Title: |
Small
8 |
Publikationsportal JuSER |
Guiding of neuronal cells on surfaces is required for the investigation of fundamental aspects of neurobiology, for tissue engineering, and for numerous bioelectronic applications. A modular method to establish nanostructured chemical templates for local deposition of gold nanoparticles is presented. A process comprising nanoimprint lithography, silanization, lift-off, and gold nanoparticle immobilization is used to fabricate the particle patterns. The chemical composition of the surface can be modified by in situ adsorption of cell-binding ligands to locally addressed particles. The versatility of this approach is demonstrated by inverting the binding affinity between rat cortical neurons and nanopatterned surfaces via wet-chemical means and thereby reversing the pattern of guided neurons. |