This title appears in the Scientific Report :
2012
Please use the identifier:
http://dx.doi.org/10.1002/ana.23663 in citations.
Coordinated reset has sustained aftereffects in Parkinsonian monkeys.
Coordinated reset has sustained aftereffects in Parkinsonian monkeys.
Coordinated reset neuromodulation consists of the application of consecutive brief high-frequency pulse trains through the different contacts of the stimulation electrode. In theoretical studies, by achieving unlearning of abnormal connectivity between neurons, coordinated reset neuromodulation redu...
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Personal Name(s): | Tass, Peter A. (Corresponding author) |
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Qin, Li / Hauptmann, Christian / Dovero, Sandra / Bezard, Erwan / Boraud, Thomas / Meissner, Wassilios G | |
Contributing Institute: |
Gehirn & Verhalten; INM-7 |
Published in: | Annals of neurology, 72 (2012) 5, S. 816 - 820 |
Imprint: |
Hoboken, NJ
Wiley-Blackwell
2012
|
PubMed ID: |
23280797 |
DOI: |
10.1002/ana.23663 |
Document Type: |
Journal Article |
Research Program: |
(Dys-)function and Plasticity Pathophysiological Mechanisms of Neurological and Psychiatric Diseases |
Publikationsportal JuSER |
Coordinated reset neuromodulation consists of the application of consecutive brief high-frequency pulse trains through the different contacts of the stimulation electrode. In theoretical studies, by achieving unlearning of abnormal connectivity between neurons, coordinated reset neuromodulation reduces pathological synchronization, a hallmark feature of Parkinson's disease pathophysiology. Here we show that coordinated reset neuromodulation of the subthalamic nucleus has both acute and sustained long-lasting aftereffects on motor function in parkinsonian nonhuman primates. Long-lasting aftereffects were not observed with classical deep brain stimulation. These observations encourage further development of coordinated reset neuromodulation for treating motor symptoms in Parkinson disease patients. ANN NEUROL 2012;72:816-820. |