This title appears in the Scientific Report :
2012
Please use the identifier:
http://dx.doi.org/10.1109/IEMBS.2011.6090148 in citations.
The translational value of the MPTP non-human primate model of Parkinsonism for deep brain stimulation research.
The translational value of the MPTP non-human primate model of Parkinsonism for deep brain stimulation research.
Deep brain stimulation (DBS) has been applied in more than 70000 patients worldwide during the last two decades. The main target is the subthalamic nucleus (STN) for the treatment of motor complications in late stage Parkinson's disease (PD). Positive results in 1-methyl-4-phenyl-1,2,3,6-tetrah...
Saved in:
Personal Name(s): | Tass, Peter A. (Corresponding author) |
---|---|
Qin, Li / Hauptmann, Christian / Dovero, Sandra / Bezard, Erwan / Boraud, Thomas / Meissner, Wassilios G | |
Contributing Institute: |
Gehirn & Verhalten; INM-7 |
Published in: | IEEE engineering in medicine and biology magazine, - S. 663 - 666 |
Imprint: |
New York, NY
IEEE
2011
|
DOI: |
10.1109/IEMBS.2011.6090148 |
PubMed ID: |
22254396 |
Conference: | 2011 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Boston, MA 30-08-2011 - 3-09-2011 |
Document Type: |
Journal Article |
Research Program: |
(Dys-)function and Plasticity Pathophysiological Mechanisms of Neurological and Psychiatric Diseases |
Subject (ZB): | |
Publikationsportal JuSER |
Deep brain stimulation (DBS) has been applied in more than 70000 patients worldwide during the last two decades. The main target is the subthalamic nucleus (STN) for the treatment of motor complications in late stage Parkinson's disease (PD). Positive results in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated non-human primates have set the grounds for its successful translation to PD patients. Since then, this model has allowed gaining significant insights in the underlying mechanisms of action of DBS and is currently being used for the development of new stimulation techniques. Altogether, this underpins the high potential of this preclinical model for future translation of DBS research in PD. |