This title appears in the Scientific Report :
2014
Please use the identifier:
http://dx.doi.org/10.1002/adhm.201300062 in citations.
Please use the identifier: http://hdl.handle.net/2128/15764 in citations.
Boron-Doped Nanocrystalline Diamond Microelectrode Arrays Monitor Cardiac Action Potentials
Boron-Doped Nanocrystalline Diamond Microelectrode Arrays Monitor Cardiac Action Potentials
The expansion of diamond-based electronics in the area of biological interfacing has not been as thoroughly explored as applications in electrochemical sensing. However, the biocompatibility of diamond, large safe electrochemical window, stability, and tunable electronic properties provide opportuni...
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Personal Name(s): | Maybeck, Vanessa (Corresponding author) |
---|---|
Edgington, Robert / Bongrain, Alexandre / Welch, Joseph O. / Scorsone, Emanuel / Bergonzo, Philippe / Jackman, Richard B. / Offenhäusser, Andreas | |
Contributing Institute: |
Jülich-Aachen Research Alliance - Fundamentals of Future Information Technology; JARA-FIT Bioelektronik; PGI-8 Bioelektronik; ICS-8 |
Published in: | Advanced Healthcare Materials, 3 (2014) 2, S. 283–289 |
Imprint: |
Weinheim
Wiley-VCH
2014
|
DOI: |
10.1002/adhm.201300062 |
Document Type: |
Journal Article |
Research Program: |
Physics of the Cell Sensorics and bioinspired systems |
Link: |
OpenAccess OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://hdl.handle.net/2128/15764 in citations.
The expansion of diamond-based electronics in the area of biological interfacing has not been as thoroughly explored as applications in electrochemical sensing. However, the biocompatibility of diamond, large safe electrochemical window, stability, and tunable electronic properties provide opportunities to develop new devices for interfacing with electrogenic cells. Here, the fabrication of microelectrode arrays (MEAs) with boron-doped nanocrystalline diamond (BNCD) electrodes and their interfacing with cardiomyocyte-like HL-1 cells to detect cardiac action potentials are presented. A nonreductive means of structuring doped and undoped diamond on the same substrate is shown. The resulting BNCD electrodes show high stability under mechanical stress generated by the cells. It is shown that by fabricating the entire surface of the MEA with NCD, in patterns of conductive doped, and isolating undoped regions, signal detection may be improved up to four-fold over BNCD electrodes passivated with traditional isolators. |