This title appears in the Scientific Report : 2014 

Dopamine Replacement Modulates Oscillatory Coupling Between Premotor and Motor Cortical Areas in Parkinson's Disease.
Herz, D. M. (Corresponding author)
Florin, E. / Christensen, M. S. / Reck, C. / Barbe, Michael / Tscheuschler, M. K. / Tittgemeyer, M. / Siebner, H. R. / Timmermann, L.
Kognitive Neurowissenschaften; INM-3
Cerebral cortex, 24 (2014) 11, S. 2873-2883
Oxford Oxford Univ. Press 2014
10.1093/cercor/bht140
Journal Article
(Dys-)function and Plasticity
Pathophysiological Mechanisms of Neurological and Psychiatric Diseases
OpenAccess
Please use the identifier: http://hdl.handle.net/2128/8035 in citations.
Please use the identifier: http://dx.doi.org/10.1093/cercor/bht140 in citations.
Efficient neural communication between premotor and motor cortical areas is critical for manual motor control. Here, we used high-density electroencephalography to study cortical connectivity in patients with Parkinson's disease (PD) and age-matched healthy controls while they performed repetitive movements of the right index finger at maximal repetition rate. Multiple source beamformer analysis and dynamic causal modeling were used to assess oscillatory coupling between the lateral premotor cortex (lPM), supplementary motor area (SMA), and primary motor cortex (M1) in the contralateral hemisphere. Elderly healthy controls showed task-related modulation in connections from lPM to SMA and M1, mainly within the γ-band (>30 Hz). Nonmedicated PD patients also showed task-related γ-γ coupling from lPM to M1, but γ coupling from lPM to SMA was absent. Levodopa reinstated physiological γ-γ coupling from lPM to SMA and significantly strengthened coupling in the feedback connection from M1 to lPM expressed as β-β as well as θ-β coupling. Enhancement in cross-frequency θ-β coupling from M1 to lPM was correlated with levodopa-induced improvement in motor function. The results show that PD is associated with an altered neural communication between premotor and motor cortical areas, which can be modulated by dopamine replacement.