This title appears in the Scientific Report : 2011 

Nanostructuring of CyPlos (cyclic phosphate-linked oligosaccharides), novel saccharide-based synthetic ion transporters
Mangiapia, G.
Coppola, C. / Vitiello, G. / d'Errico, G. / deNapoli, L. / Radulescu, A. / Montesarchio, D. / Paduano, L.
JCNS; JCNS
Neutronenstreuung; ICS-1
Streumethoden; PGI-4
Journal of colloid and interface science, 354 (2011) S. 718 - 724
Amsterdam [u.a.] Elsevier 2011
718 - 724
21111429
10.1016/j.jcis.2010.10.060
Journal Article
Großgeräte für die Forschung mit Photonen, Neutronen und Ionen (PNI)
BioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung
Journal of Colloid and Interface Science 354
J
Please use the identifier: http://dx.doi.org/10.1016/j.jcis.2010.10.060 in citations.
Ionophores are an important class of synthetic molecules which mimic natural ion channels or carriers. Here we report the aggregation behavior in pseudo-physiological environment of three Cyclic Phosphate-Linked Oligosaccharides (CyPLOS) derivatives, synthetic ion transporters based on cyclic, phosphate-linked disaccharide skeleton differing for the nature of the tails (tetraethylene-TEG glycol and/or n-undecyl chains) attached to the C-2 and C-3 of the constitutive monosaccharides. Their aggregation behavior has been studied by a combined use of dynamic light scattering (DLS), electron paramagnetic resonance spectroscopy (EPR) and Small Angle Neutron Scattering (SANS). DLS measurements were performed to reveal the formation and size distribution of the CyPLOS aggregates. EPR measurements, by using 5-doxyl stearic acid (5-DSA) as spin-probe, showed that the aggregates are mainly due to the formation of double layers and allowed to analyze the local fluidity. Finally, SANS measurements allowed estimating the layer thickness of the double layers. Our results indicate that the three CyPLOS analogs show self-aggregation properties that depend on the different nature of the inserted tails.