This title appears in the Scientific Report :
2010
Please use the identifier:
http://dx.doi.org/10.2967/jnumed.109.071423 in citations.
Comparison of O-(2-[18F]fluoroethyl)-L-tyrosine and L-[3H]-methionine uptake in cerebral hematomas
Comparison of O-(2-[18F]fluoroethyl)-L-tyrosine and L-[3H]-methionine uptake in cerebral hematomas
Radiolabeled amino acids are useful for brain tumor diagnosis, but unspecific uptake near the cerebral hematoma may complicate the differentiation of a neoplastic from a nonneoplastic origin of the hematoma. The aim of this study was to investigate the pattern and time course of O-(2-(18)F-fluorethy...
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Personal Name(s): | Salber, D. |
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Stoffels, G. / Oros-Peusquens, A.M. / Shah, N.J. / Reifenberger, G. / Hamacher, K. / Coenen, H.H. / Langen, K.J. | |
Contributing Institute: |
Nuklearchemie; INM-5 JARA-BRAIN; JARA-BRAIN Physik der Medizinischen Bildgebung; INM-4 |
Published in: | Journal of Nuclear Medicine Journal of nuclear medicine, 51 51 (2010 2010) 5 5, S. 790-797 790-797 |
Imprint: |
New York, NY
Society of Nuclear Medicine
2010
2010-04-15 2010-05-01 2010-05-01 |
Physical Description: |
790 - 797 |
DOI: |
10.2967/jnumed.109.071423 |
PubMed ID: |
20395334 |
Document Type: |
Journal Article |
Research Program: |
Neuroimaging Funktion und Dysfunktion des Nervensystems |
Series Title: |
Journal of Nuclear Medicine
51 |
Subject (ZB): | |
Publikationsportal JuSER |
Radiolabeled amino acids are useful for brain tumor diagnosis, but unspecific uptake near the cerebral hematoma may complicate the differentiation of a neoplastic from a nonneoplastic origin of the hematoma. The aim of this study was to investigate the pattern and time course of O-(2-(18)F-fluorethyl)-l-tyrosine ((18)F-FET) and l-(3)H-methionine ((3)H-MET) uptake in rats with cerebral hematomas.Intracerebral hematomas were induced in the striatum of 25 Fischer 344 CDF rats by inoculation of bacterial collagenase. (18)F-FET and (3)H-MET were injected intravenously at different times up to 4 wk after bleeding. One hour after tracer injection, brains were cut in coronal sections and evaluated by dual-tracer autoradiography. Lesion-to-brain (L/B) ratios were calculated by dividing maximal uptake near the hematomas and mean uptake in normal brain tissue. An L/B ratio greater than 1.5 was considered as indicative of pathologic uptake. The autoradiograms were compared with histology and immunostainings for astrogliosis (glial fibrillary acidic protein) and macrophage infiltration (CD68).(18)F-FET exhibited significantly increased uptake near the hematomas between 3 and 14 d after bleeding. The time course of pathologic (3)H-MET uptake was similar, but after 3-4 wk there was still borderline uptake in single animals. The L/B ratios exceeded the cutoff level of 1.5 in 10 of 23 animals for (18)F-FET and in 12 of 22 animals for (3)H-MET but did not exceed a value of 3. Immunostainings indicated that increased uptake of both tracers correlated with reactive astrogliosis, whereas (3)H-MET uptake was additionally increased in areas with macrophage infiltration.(18)F-FET, like (3)H-MET, may exhibit significantly increased uptake near cerebral hematomas, especially during the first 2 wk after bleeding, complicating the differentiation between a neoplastic and a nonneoplastic origin of cerebral hematomas. |