This title appears in the Scientific Report :
2014
Please use the identifier:
http://dx.doi.org/10.1007/978-3-642-42014-6_7 in citations.
Imaging of Adenosine Receptors
Imaging of Adenosine Receptors
Adenosine is a fundamental molecule of life. It is a part of the DNA and the main degradation product of the central currency of energy metabolism in humans and animals – adenosine triphosphate (ATP). Under pathological conditions like hypoxia, the adenosine concentration can rise severalfold – up t...
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Personal Name(s): | Elmenhorst, David (Corresponding author) |
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Bier, Dirk / Holschbach, Marcus / Bauer, Andreas | |
Contributing Institute: |
Molekulare Organisation des Gehirns; INM-2 Nuklearchemie; INM-5 |
Published in: |
PET and SPECT of Neurobiological Systems |
Imprint: |
Berlin, Heidelberg
Springer Berlin Heidelberg
2014
|
Physical Description: |
181-198 |
ISBN: |
978-3-642-42013-9 |
DOI: |
10.1007/978-3-642-42014-6_7 |
Document Type: |
Contribution to a book |
Research Program: |
Pathophysiological Mechanisms of Neurological and Psychiatric Diseases |
Edition: | Chapter 7 |
Publikationsportal JuSER |
Adenosine is a fundamental molecule of life. It is a part of the DNA and the main degradation product of the central currency of energy metabolism in humans and animals – adenosine triphosphate (ATP). Under pathological conditions like hypoxia, the adenosine concentration can rise severalfold – up to micromolar concentrations. The net effect of adenosine on excitable tissue is inhibitory affecting the release of classical neurotransmitters like glutamate, GABA (gamma-aminobutyric acid), and dopamine. The widely used neurostimulant caffeine exerts its effects as an antagonist at adenosine receptors. Four different types of adenosine receptors have been described in mammals: A1, A2A, A2B, and A3 which are all G-protein-coupled receptors. Over the last 25 years, adenosine receptor ligands, agonists as well as antagonists, have emerged as a class of useful therapeutics. For the A1 and A2A subtypes several antagonist radioligands have been used successfully for PET imaging in humans and animals especially for the brain. |