This title appears in the Scientific Report :
2014
Please use the identifier:
http://dx.doi.org/10.1055/s-0034-1371201 in citations.
Are individual responses to theta-burst rTMS in cortical excitability related to changes in motor network connectivity?
Are individual responses to theta-burst rTMS in cortical excitability related to changes in motor network connectivity?
Intermittent theta-burst stimulation (iTBS) effectively increases cortical excitability within the human brain (Huang et al., 2005). However, individual after-effects of iTBS vary between subjects, with a large proportion not responding at all in terms of changes in excitability (Ridding and Ziemann...
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Personal Name(s): | Nettekoven, C. (Corresponding Author) |
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Volz, LJ / Kutscha, M. / Eickhoff, Simon / Grefkes, C. | |
Contributing Institute: |
Kognitive Neurowissenschaften; INM-3 Strukturelle und funktionelle Organisation des Gehirns; INM-1 |
Published in: | Klinische Neurophysiologie, 45 (2014) 01, S. V22 |
Imprint: |
Stuttgart [u.a.]
Thieme
2014
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Physical Description: |
45 |
DOI: |
10.1055/s-0034-1371201 |
Conference: | 58. Jahrestagung der Deutschen Gesellschaft für Klinische Neurophysiologie und Funktionelle Bildgebung (DGKN), Berlin (Germany), 2014-03-19 - 2014-03-22 |
Document Type: |
Contribution to a conference proceedings Journal Article |
Research Program: |
(Dys-)function and Plasticity Pathophysiological Mechanisms of Neurological and Psychiatric Diseases |
Publikationsportal JuSER |
Intermittent theta-burst stimulation (iTBS) effectively increases cortical excitability within the human brain (Huang et al., 2005). However, individual after-effects of iTBS vary between subjects, with a large proportion not responding at all in terms of changes in excitability (Ridding and Ziemann, 2010; Hamada et al., 2013). We here investigated whether subjects responding to iTBS show differential changes in resting-state functional connectivity (rsFC) within the cortical motor system compared to subjects with no response.14 healthy, right-handed subjects (m = 7, 27 ± 3 years) received iTBS over the left primary motor cortex (M1) on two days, separated by at least one week. Before and after iTBS-application (i) motor-evoked potentials (MEPs) or (ii) resting-state functional magnetic resonance imaging (fMRI) was assessed. Seed-based whole-brain rsFC was computed for the stimulated M1.Subjects were divided into groups of responders and non-responders according to iTBS-induced changes in MEPs (criterion: increase of at least 10% compared to baseline). Following iTBS, rsFC between M1 and premotor areas was significantly higher in responders compared to both baseline (p ≤0.001, FWE-corrected) and non-responders (p ≤0.001, FWE-corrected). Furthermore, non-responders featured higher levels of pre-interventional rsFC compared to responders (p = 0.061, FWE-corrected). Individual changes in MEPs and rsFC did not correlate.Significant iTBS-induced modulations of rsFC were exclusively found for the group of iTBS-responders, suggesting that changes in cortical excitability and motor network rsFC are related. However, no linear correlation between changes in MEP-amplitudes and rsFC was evident. Furthermore, higher levels of pre-interventional rsFC might prevent iTBS-induced strengthening of premotor-M1 connections, possibly underlying the non-responsiveness to iTBS |