This title appears in the Scientific Report :
2014
Please use the identifier:
http://dx.doi.org/10.1007/s00253-014-5782-8 in citations.
Application of metabolic engineering for the biotechnological production of L-valine
Application of metabolic engineering for the biotechnological production of L-valine
The branched chain amino acid l-valine is an essential nutrient for higher organisms, such as animals and humans. Besides the pharmaceutical application in parenteral nutrition and as synthon for the chemical synthesis of e.g. herbicides or anti-viral drugs, l-valine is now emerging into the feed ma...
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Personal Name(s): | Oldiges, Marco (Corresponding Author) |
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Eikmanns, Bernhard J. / Blombach, Bastian | |
Contributing Institute: |
Biotechnologie; IBG-1 |
Published in: | Applied microbiology and biotechnology, 98 (2014) 13, S. 5859 - 5870 |
Imprint: |
Berlin
Springer
2014
|
PubMed ID: |
24816722 |
DOI: |
10.1007/s00253-014-5782-8 |
Document Type: |
Review Journal Article |
Research Program: |
ohne Topic |
Publikationsportal JuSER |
The branched chain amino acid l-valine is an essential nutrient for higher organisms, such as animals and humans. Besides the pharmaceutical application in parenteral nutrition and as synthon for the chemical synthesis of e.g. herbicides or anti-viral drugs, l-valine is now emerging into the feed market, and significant increase of sales and world production is expected. In accordance, well-known microbial production bacteria, such as Escherichia coli and Corynebacterium glutamicum strains, have recently been metabolically engineered for efficient l-valine production under aerobic or anaerobic conditions, and the respective cultivation and production conditions have been optimized. This review summarizes the state of the art in l-valine biosynthesis and its regulation in E. coli and C. glutamicum with respect to optimal metabolic network for microbial l-valine production, genetic strain engineering and bioprocess development for l-valine production, and finally, it will shed light on emerging technologies that have the potential to accelerate strain and bioprocess engineering in the near future. |