This title appears in the Scientific Report :
2014
Please use the identifier:
http://dx.doi.org/10.1038/jcbfm.2014.92 in citations.
Comparison of cerebral blood flow acquired by simultaneous [15O]water positron emission tomography and arterial spin labeling magnetic resonance imaging
Comparison of cerebral blood flow acquired by simultaneous [15O]water positron emission tomography and arterial spin labeling magnetic resonance imaging
Until recently, no direct comparison between [15O]water positron emission tomography (PET) and arterial spin labeling (ASL)for measuring cerebral blood flow (CBF) was possible. With the introduction of integrated, hybrid magnetic resonance (MR)-PETscanners, such a comparison becomes feasible. This s...
Saved in:
Personal Name(s): | Zhang, Ke (Corresponding Author) |
---|---|
Herzog, Hans / Mauler, Jörg / Filss, Christian / Okell, Thomas W / Rota Kops, Elena / Tellmann, Lutz / Fischer, Thomas / Brocke, Burkhard / Sturm, Walter / Coenen, Heinrich Hubert / Shah, N. J. | |
Contributing Institute: |
JARA-BRAIN; JARA-BRAIN Physik der Medizinischen Bildgebung; INM-4 |
Published in: | Journal of cerebral blood flow & metabolism, 34 (2014) 8, S. 1373-1380 |
Imprint: |
[s.l.]
Nature
2014
|
DOI: |
10.1038/jcbfm.2014.92 |
Document Type: |
Journal Article |
Research Program: |
Neuroimaging Imaging the Living Brain |
Publikationsportal JuSER |
Until recently, no direct comparison between [15O]water positron emission tomography (PET) and arterial spin labeling (ASL)for measuring cerebral blood flow (CBF) was possible. With the introduction of integrated, hybrid magnetic resonance (MR)-PETscanners, such a comparison becomes feasible. This study presents results of CBF measurements recorded simultaneously with[15O]water and ASL. A 3T MR-BrainPET scanner was used for the simultaneous acquisition of pseudo-continuous ASL (pCASL)magnetic resonance imaging (MRI) and [15O]water PET. Quantitative CBF values were compared in 10 young healthy malevolunteers at baseline conditions. A statistically significant (Po0.05) correlation was observed between the two modalities; thewhole-brain CBF values determined with PET and pCASL were 43.3±6.1 mL and 51.9±7.1 mL per 100 g per minute, respectively.The gray/white matter (GM/WM) ratio of CBF was 3.0 for PET and 3.4 for pCASL. A paired t-test revealed differences in regional CBFbetween ASL and PET with higher ASL-CBF than PET-CBF values in cortical areas. Using an integrated, hybrid MR-PET a directsimultaneous comparison between ASL and [15O]water PET became possible for the first time so that temporal, physiologic, andfunctional variations were avoided. Regional and individual differences were found despite the overall similarity between ASL andPET, requiring further detailed investigations. |