This title appears in the Scientific Report : 2014 

Neuropeptide Receptors in Pain Circuitries: Useful Targets for CNS Imaging with Non-Peptide Ligands Suitable for PET?
Pissarek, Margit (Corresponding Author)
Nuklearchemie; INM-5
World Journal of Neuroscience, 04 (2014) 04, S. 353 - 383
Irvine, CA Scientific Research Publ. 2014
Journal Article
Pathophysiological Mechanisms of Neurological and Psychiatric Diseases
Please use the identifier: in citations.
Please use the identifier: in citations.
Neuropeptide receptors of the brain and spinal cord are parts of the pain circuits targeted byanalgesic drugs. Some of these receptors have been found in the central nervous system as well asin intracranial vascular structures and achieved revival of attention because of their role in acuteand chronic pain syndromes. A number of them are of high clinical relevance for e.g. migraine.Others participate in symptoms of rare diseases like amyotrophic lateral sclerosis. Here we willfocus on five of the neuropeptide receptors and their non-peptide ligands potentially or alreadysuccessfully used as PET probes. Opioid receptors and neurotensin receptors are known tomediate analgesic actions. Bradykinin and calcitonin gene-related peptide (CGRP) receptors areknown to be involved in the regulation of vascular tone and inflammatory responses, and neurokininreceptors play a role in the occurrence of pain perception in a rather indirect manner. Mostexperiences as PET tracers have been gathered with opioid receptor ligands and neurokininreceptor ligands. The most innovative fields revealed by the studies summarized in this report arethe ligands of κ opioid receptors and CGRP receptors for which a first PET tracer was presentedrecently.