This title appears in the Scientific Report :
2011
Please use the identifier:
http://dx.doi.org/10.3233/RNN-2011-0601 in citations.
Isometric contraction interferes with transcranial direct current stimulation (tDCS) induced plasticity - evidence of state-dependent neuromodulation in human motor cortex
Isometric contraction interferes with transcranial direct current stimulation (tDCS) induced plasticity - evidence of state-dependent neuromodulation in human motor cortex
Neuroplastic alterations of cortical excitability and activity represent the likely neurophysiological foundation of learning and memory formation. Beyond their induction, alterations of these processes by subsequent modification of cortical activity, termed metaplasticity, came into the focus of in...
Saved in:
Personal Name(s): | Thirugnanasambandam, N. |
---|---|
Sparing, R. / Dafotakis, M. / Meister, I.G. / Pauls, W. / Nitsche, M.A. / Fink, G.R. | |
Contributing Institute: |
Kognitive Neurowissenschaften; INM-3 |
Published in: | Restorative neurology and neuroscience, 29 (2011) S. 311 - 320 |
Imprint: |
Amsterdam
IOS Press
2011
|
Physical Description: |
311 - 320 |
DOI: |
10.3233/RNN-2011-0601 |
PubMed ID: |
21697590 |
Document Type: |
Journal Article |
Research Program: |
(Dys-)function and Plasticity Funktion und Dysfunktion des Nervensystems |
Series Title: |
Restorative Neurology and Neuroscience
29 |
Subject (ZB): | |
Publikationsportal JuSER |
Neuroplastic alterations of cortical excitability and activity represent the likely neurophysiological foundation of learning and memory formation. Beyond their induction, alterations of these processes by subsequent modification of cortical activity, termed metaplasticity, came into the focus of interest recently. Animal slice experiments demonstrated that neuroplastic excitability enhancements, or diminutions, can be abolished by consecutive subthreshold stimulation. These processes, termed de-potentiation, and de-depression, have so far not been explored in humans.We combined neuroplasticity induction by transcranial direct current stimulation (tDCS) applied to the hand area of primary motor cortex (M1), which can be used to induce long-lasting excitability enhancements or reductions, dependent on the polarity of stimulation, with short-lasting voluntary muscle contraction (VMC), which itself does not induce plastic cortical excitability changes. Corticospinal and intra-cortical M1 excitability were monitored by different transcranial magnetic stimulation (TMS) protocols.VMC reduced or tended to reverse the anodal tDCS-driven motor cortical excitability enhancement and the cathodal tDCS-induced excitability diminution. Our findings thus demonstrate de-potentiation- and de-depression-like phenomena at the system level in the human motor cortex.This neurophysiological study may contribute to a better understanding of the balance between induction and reversal of plasticity associated with motor learning and rehabilitation processes. |