This title appears in the Scientific Report :
2011
Please use the identifier:
http://dx.doi.org/10.3390/molecules16097621 in citations.
Synthesis of No-Carrier-Added 4-[(18)F]Fluorophenol from 4-Benzyloxyphenyl-(2-thienyl)iodonium Bromide
Synthesis of No-Carrier-Added 4-[(18)F]Fluorophenol from 4-Benzyloxyphenyl-(2-thienyl)iodonium Bromide
4-[(18)F]Fluorophenol is a versatile synthon for the synthesis of more complex radiopharmaceuticals bearing a 4-[(18)F]fluorophenoxy moiety. In order to prepare 4-[(18)F]fluorophenol in no-carrier-added (n.c.a.) form only a nucleophilic labelling method starting from [(18)F]fluoride is suitable. In...
Saved in:
Personal Name(s): | Ross, T.L. |
---|---|
Ermert, J. / Coenen, H.H. | |
Contributing Institute: |
Nuklearchemie; INM-5 |
Published in: | Molecules, 16 (2011) S. 7621 - 7626 |
Imprint: |
Basel
MDPI
2011
|
Physical Description: |
7621 - 7626 |
DOI: |
10.3390/molecules16097621 |
PubMed ID: |
21900864 |
Document Type: |
Journal Article |
Research Program: |
Neuroimaging Funktion und Dysfunktion des Nervensystems |
Series Title: |
Molecules
16 |
Subject (ZB): | |
Publikationsportal JuSER |
4-[(18)F]Fluorophenol is a versatile synthon for the synthesis of more complex radiopharmaceuticals bearing a 4-[(18)F]fluorophenoxy moiety. In order to prepare 4-[(18)F]fluorophenol in no-carrier-added (n.c.a.) form only a nucleophilic labelling method starting from [(18)F]fluoride is suitable. In this paper a new, two step radiosynthesis starting from 4-benzyloxyphenyl-(2-thienyl)iodonium bromide and [(18)F]fluoride with subsequent deprotection is described, yielding n.c.a. [(18)F]fluorophenol in 34 to 36% radiochemical yield. |