This title appears in the Scientific Report :
2011
Please use the identifier:
http://dx.doi.org/10.1016/j.ijrobp.2010.01.055 in citations.
Prognostic value of early 18F-fluoroethylryrosine PET after radiochemotherapy in glioblastoma multiforme
Prognostic value of early 18F-fluoroethylryrosine PET after radiochemotherapy in glioblastoma multiforme
Early detection of treatment response in glioma patients after radiochemotherapy (RCX) is uncertain because treatment-related contrast enhancement in magnetic resonance imaging can mimic tumor progression. Positron emission tomography (PET) using the amino acid tracer [(18)F]fluoroethyltyrosine (FET...
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Personal Name(s): | Piroth, M.D. |
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Pinkawa, M. / Holy, R. / Klotz, J. / Nussen, S. / Stoffels, G. / Coenen, H.H. / Kaiser, J.H. / Langen, K.J. / Eble, M.J. | |
Contributing Institute: |
Physik der Medizinischen Bildgebung; INM-4 Nuklearchemie; INM-5 |
Published in: | International journal of radiation oncology, biology, physics, 80 (2011) S. 176 - 184 |
Imprint: |
Amsterdam [u.a.]
Elsevier Science
2011
|
Physical Description: |
176 - 184 |
PubMed ID: |
20646863 |
DOI: |
10.1016/j.ijrobp.2010.01.055 |
Document Type: |
Journal Article |
Research Program: |
Neurowissenschaften |
Series Title: |
International Journal of Radiation Oncology Biology Physics
80 |
Subject (ZB): | |
Publikationsportal JuSER |
Early detection of treatment response in glioma patients after radiochemotherapy (RCX) is uncertain because treatment-related contrast enhancement in magnetic resonance imaging can mimic tumor progression. Positron emission tomography (PET) using the amino acid tracer [(18)F]fluoroethyltyrosine (FET) seems to be a promising tool for treatment monitoring. The aim of this prospective study was to evaluate the prognostic value of early changes of FET uptake after postoperative RCX in glioblastomas.Twenty-two patients with glioblastoma were treated by surgery and subsequent RCX (whole dose 60-72 Gy). The FET-PET studies were performed before RCX, 7-10 days and 6-8 weeks after completion of RCX. Early treatment response in PET was defined as a decrease of the maximal tumor-to-brain ratio (TBR(max)) of FET uptake after RCX of more than 10%. The prognostic value of early changes of FET uptake after RCX was evaluated using Kaplan-Maier estimates for median disease-free survival and overall survival.The median overall and disease-free survival of the patients was 14.8 and 7.8 months. There were 16 early responders in FET-PET (72.7%) and 6 nonresponders (27.3%). Early PET responders had a significantly longer median disease-free survival (10.3 vs. 5.8 months; p < 0.01) and overall survival ("not reached" vs. 9.3 months; p < 0.001). No statistically significant differences between the patient subgroups were found concerning the defined prognostic parameters.FET-PET is a sensitive tool to predict treatment response in patients with glioblastomas at an early stage after RCX. |