This title appears in the Scientific Report :
2011
Please use the identifier:
http://dx.doi.org/10.1039/C0LC00582G in citations.
Please use the identifier: http://hdl.handle.net/2128/7320 in citations.
Nanocavity electrode array for recording from electrogenic cells
Nanocavity electrode array for recording from electrogenic cells
We present a new nanocavity device for highly localized on-chip recordings of action potentials from individual cells in a network. Microelectrode recordings have become the method of choice for recording extracellular action potentials from high density cultures or slices. Nevertheless, interfacing...
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Personal Name(s): | Hofmann, B. |
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Kätelhön, E. / Schottdorf, M. / Offenhäusser, A. / Wolfrum, B. | |
Contributing Institute: |
Bioelektronik; ICS-8 Bioelektronik; PGI-8 JARA-FIT; JARA-FIT |
Published in: | Lab on a chip, 11 (2011) S. 1054-1058 |
Imprint: |
Cambridge
RSC
2011
|
Physical Description: |
1054-1058 |
DOI: |
10.1039/C0LC00582G |
PubMed ID: |
21286648 |
Document Type: |
Journal Article |
Research Program: |
BioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung Grundlagen für zukünftige Informationstechnologien |
Series Title: |
Lab on a Chip
11 |
Subject (ZB): | |
Link: |
Get full text Published under German "Allianz" Licensing conditions on 2011-02-01. Available in OpenAccess from 2012-02-01 |
Publikationsportal JuSER |
Please use the identifier: http://hdl.handle.net/2128/7320 in citations.
We present a new nanocavity device for highly localized on-chip recordings of action potentials from individual cells in a network. Microelectrode recordings have become the method of choice for recording extracellular action potentials from high density cultures or slices. Nevertheless, interfacing individual cells of a network with high resolution still remains challenging due to an insufficient coupling of the signal to small electrodes, exhibiting diameters below 10 µm. We show that this problem can be overcome by a new type of sensor that features an electrode, which is accessed via a small aperture and a nanosized cavity. Thus, the properties of large electrodes are combined with a high local resolution and a good seal resistance at the interface. Fabrication of the device can be performed with state-of-the-art clean room technology and sacrificial layer etching allowing integration of the devices into sensor arrays. We demonstrate the capability of such an array by recording the propagation of action potentials in a network of cardiomyocyte-like cells. |