This title appears in the Scientific Report :
2011
Please use the identifier:
http://dx.doi.org/10.1007/s12104-011-9299-0 in citations.
1H, 15N and 13³C resonance assignment of the N-terminal C39 peptidase-like domain of the ABC transporter Haemolysin B (HlyB)
1H, 15N and 13³C resonance assignment of the N-terminal C39 peptidase-like domain of the ABC transporter Haemolysin B (HlyB)
ATP-binding cassette (ABC) transporters are ubiquitous integral membrane proteins, which catalyze the translocation of molecules across biological membranes in an ATP-dependent manner. Despite the diversity in the transported substrates, they all share the same architecture, comprised of two transme...
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Personal Name(s): | Lecher, J. |
---|---|
Stoldt, M. / Schwarz, C.K.W. / Smits, S.H.J. / Schmitt, L. / Willbold, D. | |
Contributing Institute: |
Strukturbiochemie; ICS-6 |
Published in: | Biomolecular NMR assignments, 5 (2011) S. 199 - 201 |
Imprint: |
Dordrecht [u.a.]
Springer Netherlands
2011
|
Physical Description: |
199 - 201 |
DOI: |
10.1007/s12104-011-9299-0 |
PubMed ID: |
21347827 |
Document Type: |
Journal Article |
Research Program: |
BioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung Funktion und Dysfunktion des Nervensystems |
Series Title: |
Biomolecular NMR Assignments
5 |
Subject (ZB): | |
Publikationsportal JuSER |
ATP-binding cassette (ABC) transporters are ubiquitous integral membrane proteins, which catalyze the translocation of molecules across biological membranes in an ATP-dependent manner. Despite the diversity in the transported substrates, they all share the same architecture, comprised of two transmembrane (TMD) and two nucleotide-binding domains (NBD). Members of the bacteriocin ABC transporter subfamily feature a special domain, belonging to the C39 (cystein protease family 39) peptidase protein family. These domains are assumed to cleave a C-terminal signal sequence from the protein or peptide substrate before or during the transport process. Although the C39 peptidase-like domain of the ABC transporter haemolysin B from E. coli shows no proteolytic activity, it is essential for the function of this transporter. In order to elucidate the contribution of the isolated C39 peptidase-like domain in the whole transport process, the backbone and side chain (1)H, (15)N and (13)C-NMR chemical shifts have been assigned. |