This title appears in the Scientific Report :
2008
Please use the identifier:
http://dx.doi.org/10.1016/j.nucmedbio.2008.08.003 in citations.
CIS-4[18F]-fluoro-L-proline fails to detect peripheral tumors in humans
CIS-4[18F]-fluoro-L-proline fails to detect peripheral tumors in humans
System A amino acid transport is increased in transformed and malignant cells. The amino acid 4-cis[(18)F]fluoro-l-proline (cis-[(18)F]FPro) has been shown to be a substrate of the System A amino acid carrier. In this pilot study, we investigated the diagnostic potential of cis-[(18)F]FPro in patien...
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Personal Name(s): | Stoffels, G. |
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Pauleit, D. / Hass, R. / Kobbe, G. / Salber, D. / Hamacher, K. / Coenen, H. H. / Langen, K.-J. | |
Contributing Institute: |
Institut für Neurowissenschaften und Biophysik - Medizin; INB-3 Nuklearchemie; INB-4 |
Published in: | Nuclear medicine and biology, 35 (2008) S. 895 - 900 |
Imprint: |
Amsterdam [u.a.]
Elsevier
2008
|
Physical Description: |
895 - 900 |
DOI: |
10.1016/j.nucmedbio.2008.08.003 |
PubMed ID: |
19026951 |
Document Type: |
Journal Article |
Research Program: |
Funktion und Dysfunktion des Nervensystems |
Series Title: |
Nuclear Medicine and Biology
35 |
Subject (ZB): | |
Publikationsportal JuSER |
System A amino acid transport is increased in transformed and malignant cells. The amino acid 4-cis[(18)F]fluoro-l-proline (cis-[(18)F]FPro) has been shown to be a substrate of the System A amino acid carrier. In this pilot study, we investigated the diagnostic potential of cis-[(18)F]FPro in patients with various tumors in comparison with [(18)F]fluorodeoxyglucose-positron emission tomography (FDG-PET).Eight patients (seven females, one male, age range 43-77 years) with large primary, recurrent or metastatic tumors of different histologies were included in this study. One patient had a recurrent non-Hodgkin lymphoma; two patients, metastatic colon or rectal cancer; one, a metastatic endometrial cancer; one, a multiple myeloma; one, an Ewing sarcoma; one, a metastatic breast cancer and one, a gastrointestinal stromal tumor. PET scans of the trunk were acquired at 1 h after intravenous injection of 400 MBq cis-[(18)F]FPro and compared to PET scans with [(18)F]FDG.None of the tumors or metastatic lesions in this series of patients demonstrated relevant uptake of cis-[(18)F]FPro. In contrast, all tumors with exception of the multiple myeloma showed an intensive uptake of [(18)F]FDG. The mean standardized uptake value of cis-[(18)F]FPro in the tumor or metastases was significantly lower than that of [(18)F]FDG uptake (1.7+/-0.6 vs. 5.7+/-3.0; n=8; P<.01).Although other System A-specific tracers have shown relevant tumor uptake, cis-[(18)F]FPro fails to detect most types of human tumors. Based on these results, we cannot recommend a further evaluation of this tracer as a tumor-seeking agent. |