This title appears in the Scientific Report :
2014
Please use the identifier:
http://hdl.handle.net/2128/8120 in citations.
The Tat translocase of $textit{Corynebacterium glutamicum}$ and the effect for TorD coexpression
The Tat translocase of $textit{Corynebacterium glutamicum}$ and the effect for TorD coexpression
White biotechnology employs microorganisms or microbial-derived enzymes for the production ofvaluable chemicals. The significance of bio-based industrial processes has been steadily increasingduring the last decades; especially in facing the risks and challenges of a growing world populationand bein...
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Personal Name(s): | Oertel, Dan (Corresponding Author) |
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Contributing Institute: |
Biotechnologie; IBG-1 |
Published in: | 2014 |
Imprint: |
Jülich
Forschungszentrum Jülich GmbH Zentralbibliothek, Verlag
2014
|
Physical Description: |
V, 117 S. |
Dissertation Note: |
Universität Düsseldorf, Diss., 2014 |
ISBN: |
978-3-89336996-6 |
Document Type: |
Dissertation / PhD Thesis |
Research Program: |
ohne Topic |
Series Title: |
Schriften des Forschungszentrums Jülich. Reihe Gesundheit / Health
75 |
Subject (ZB): | |
Link: |
OpenAccess |
Publikationsportal JuSER |
White biotechnology employs microorganisms or microbial-derived enzymes for the production ofvaluable chemicals. The significance of bio-based industrial processes has been steadily increasingduring the last decades; especially in facing the risks and challenges of a growing world populationand being able to satisfy the growing demand for fine chemicals, food additives for humans and livestockand pharmaceutical products.Modern biotechnology tries to address these needs by presenting bio-based production solutionswhich are independent of fossil-fuel carbon-sources and thus not only more sustainable but also lesshazardous in their waste production. In the course of this development, the biotechnological productionof proteins and peptides has rapidly grown in importance. While the market for industrial enzymeswas around US Dollar 3.3 billion in 2010 it is estimated to reach a value of US Dollar 4.4 billion by 2015(Adrio and Demain, 2014). Today, technical enzymes are being employed in a multitude of ways, e.g.amylases, xylanases and lipases for the baking industry, pectinases and cellulases for vegetable, fruitand wine processing and amylases and cellulases in the textile industry, many of which are producedin Bacillus spec. and fungi such as Aspergillus spec. or Trichoderma spec. (Sarrouh et al., 2012). Alsoproducts of pharmaceutical relevance such as recombinant human insulin produced in Escherichiacoli (Schmidt, 2004) or human Interferon (IFN)-γ in B. subtilis (Rojas Contreras et al., 2010) have alarge demand.Advantageous for downstream processing is the direct secretion of the desired polypeptide productinto the culture supernatant which can be accomplished with G ram-positive secretion hosts such asBacillus ssp. or Corynebacterium glutamicum. |