Description: Excitatory amino acid transporters: recent insights into molecular mechanisms, novel modes of modulation and new therapeutic possibilities.

This title appears in the Scientific Report : 2015

Excitatory amino acid transporters: recent insights into molecular mechanisms, novel modes of modulation and new therapeutic possibilities.

The five excitatory amino acid transporters (EAAT1-5) mediating the synaptic uptake of the major excitatory neurotransmitter glutamate are differently expressed throughout the CNS and at the synaptic level. Although EAATs are crucial for normal excitatory neurotransmission, explorations into the phy...

Personal Name(s):	Jensen, Anders A (Corresponding Author)
	Fahlke, Christoph / Bjørn-Yoshimoto, Walden E / Bunch, Lennart
Contributing Institute:	Zelluläre Biophysik; ICS-4
Published in:	Current opinion in pharmacology, 20 (2015) S. 116–123
Imprint:	Amsterdam [u.a.] Elsevier Science 2015
PubMed ID:	25466154
DOI:	10.1016/j.coph.2014.10.008
Document Type:	Journal Article
Research Program:	Physical Basis of Diseases
	Publikationsportal JuSER

Please use the identifier: http://dx.doi.org/10.1016/j.coph.2014.10.008 in citations.

The five excitatory amino acid transporters (EAAT1-5) mediating the synaptic uptake of the major excitatory neurotransmitter glutamate are differently expressed throughout the CNS and at the synaptic level. Although EAATs are crucial for normal excitatory neurotransmission, explorations into the physiological functions mediated by the different transporter subtypes and their respective therapeutic potential have so far been sparse, in no small part due to the limited selection of pharmacological tools available. In the present update, we outline important new insights into the molecular compositions of EAATs and their intricate transport process, the novel approaches to pharmacological modulation of the transporters that have emerged, and interesting new perspectives in EAAT as drug targets proposed in recent years.