This title appears in the Scientific Report :
2014
Please use the identifier:
http://dx.doi.org/10.1007/978-3-319-02970-2_18 in citations.
Chemosensorial G-proteins-Coupled Receptors: A Perspective from Computational Methods
Chemosensorial G-proteins-Coupled Receptors: A Perspective from Computational Methods
G-protein coupled receptors (GPCRs) constitute the targets of about 40 % of all the pharmaceutical drugs in the market and, among other functions, a large portion of the family detects odorants and a variety of tastant molecules. Computational techniques are instrumental to understand structure, dyn...
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Personal Name(s): | Musiani, Francesco |
---|---|
Rossetti, Giulia / Giorgetti, Alejandro (Corresponding Author) / Carloni, Paolo | |
Contributing Institute: |
Jülich Supercomputing Center; JSC Computational Biomedicine; INM-9 Computational Biomedicine; IAS-5 |
Published in: | 2014 |
Published in: |
Protein Conformational Dynamics |
Imprint: |
Cham
Springer International Publishing
2014
|
Physical Description: |
441 - 457 |
ISBN: |
978-3-319-02970-2 (electronic) 978-3-319-02969-6 (print) |
DOI: |
10.1007/978-3-319-02970-2_18 |
Document Type: |
Contribution to a book |
Research Program: |
Computational Science and Mathematical Methods |
Series Title: |
Advances in Experimental Medicine and Biology
805 |
Publikationsportal JuSER |
G-protein coupled receptors (GPCRs) constitute the targets of about 40 % of all the pharmaceutical drugs in the market and, among other functions, a large portion of the family detects odorants and a variety of tastant molecules. Computational techniques are instrumental to understand structure, dynamics and function of the cascades triggered by these receptors. As an example, here we report our own computational work aimed to dissect GPCR molecular mechanisms for chemical senses. The implications of our work for systems biology and for pharmacology are discussed. |