This title appears in the Scientific Report :
2014
Please use the identifier:
http://hdl.handle.net/2128/8627 in citations.
Microwire crossbar arrays for chemical, mechanical, and thermal stimulation of cells
Microwire crossbar arrays for chemical, mechanical, and thermal stimulation of cells
Over the past two decades, miniaturized biophysical tools, referred to as lab-on-a-chip or micro-total-analysis-systems, have become a vivid field of interdisciplinary research. This development is owed to the fact that these tools promise lower sample and time consumption and higher parallelization...
| Personal Name(s): | Rinklin, Philipp (Corresponding Author) |
|---|---|
| Contributing Institute: |
JARA-FIT; JARA-FIT Bioelektronik; PGI-8 |
| Published in: | 2015 |
| Imprint: |
Jülich
Forschungszentrum Jülich GmbH Zentralbibliothek, Verlag
2015
|
| Physical Description: |
XII, 182 S. |
| Dissertation Note: |
RWTH Aachen, Diss., 2014 |
| ISBN: |
978-3-95806-022-7 |
| Document Type: |
Book Dissertation / PhD Thesis |
| Research Program: |
Physical Basis of Diseases |
| Series Title: |
Schriften des Forschungszentrums Jülich. Reihe Schlüsseltechnologien / key technologies
100 |
| Subject (ZB): | |
| Link: |
OpenAccess OpenAccess |
| Publikationsportal JuSER |
|
Over the past two decades, miniaturized biophysical tools, referred to as lab-on-a-chip or micro-total-analysis-systems, have become a vivid field of interdisciplinary research. This development is owed to the fact that these tools promise lower sample and time consumption and higher parallelization than classical wet-lab experiments. At the same time, these tools can offer a resolution that is often impossible to achieve with classical probe-based techniques. In this context, the present thesis investigates the use of microwire crossbar arrays to deliver chemical, mechanical, and thermal stimuli to networks of biological cells. The first part of this work considers magnetic microparticles as transducers of chemical and mechanical stimuli. To this end, a chipbased approach to exert precise control over these particles is examined. Here, microwire crossbar arrays are used as miniaturized electromagnets to generate highly localized magnetic fields. These fields, in turn, are used to exert precise control over the particles at subcellular resolution. In order to ensure successful delivery of the particles, simple but efficient protocols for the transport of particles are investigated. In the application of these protocols, a new approach to deploy and control individual particles on-chip is introduced. This method effectively [...] |