This title appears in the Scientific Report :
2011
Please use the identifier:
http://dx.doi.org/10.1523/JNEUROSCI.4960-11.2011 in citations.
Please use the identifier: http://hdl.handle.net/2128/20575 in citations.
Hippocampal Function in Healthy Carriers of the CLU Alzheimer's Disease Risk Vairant
Hippocampal Function in Healthy Carriers of the CLU Alzheimer's Disease Risk Vairant
Alzheimer's disease is a devastating, common, progressive dementia with considerable heritability. Recently, a genetic variant associated with the disease was discovered at CLU (rs11136000) with genome-wide support. Here we show, using an imaging genetics approach in a large genotyped sample, t...
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Personal Name(s): | Erk, S. |
---|---|
Meyer-Lindenberg, A. / Opitz von Boberfeld, C. / Esslinger, C. / Schnell, K. / Kirsch, P. / Mattheisen, M. / Mühleisen, T.W. / Cichon, S. / Witt, S.H. / Rietschel, M. / Nöthen, M.M. / Walter, H. | |
Contributing Institute: |
Strukturelle und funktionelle Organisation des Gehirns; INM-1 |
Published in: | The @journal of neuroscience, 31 (2011) S. 18180 - 18184 |
Imprint: |
Washington, DC
Soc.
2011
|
Physical Description: |
18180 - 18184 |
DOI: |
10.1523/JNEUROSCI.4960-11.2011 |
PubMed ID: |
22159129 |
Document Type: |
Journal Article |
Research Program: |
Connectivity and Activity Funktion und Dysfunktion des Nervensystems |
Series Title: |
Journal of Neuroscience
31 |
Subject (ZB): | |
Link: |
Get full text OpenAccess OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://hdl.handle.net/2128/20575 in citations.
Alzheimer's disease is a devastating, common, progressive dementia with considerable heritability. Recently, a genetic variant associated with the disease was discovered at CLU (rs11136000) with genome-wide support. Here we show, using an imaging genetics approach in a large genotyped sample, that healthy carriers of the variant exhibit altered coupling between hippocampus and prefrontal cortex during memory processing, mirroring clinical evidence of disturbed connectivity in patients and providing a neurogenetic mechanism for CLU-associated risk and protection. |