The effects of a DTNBP1 gene variant on attention networks: an fMRI study
The effects of a DTNBP1 gene variant on attention networks: an fMRI study
BackgroundAttention deficits belong to the main cognitive symptoms of schizophrenia and come along with altered neural activity in previously described cerebral networks. Given the high heritability of schizophrenia the question arises if impaired function of these networks is modulated by susceptib...
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Personal Name(s): | Thimm, Markus (Corresponding Author) |
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Krug, Axel / Kellermann, Thilo / Markov, Valentin / Krach, Sören / Jansen, Andreas / Zerres, Klaus / Eggermann, Thomas / Stöcker, Tony / Shah, N. J. / Nöthen, Markus M / Rietschel, Marcella / Kircher, Tilo | |
Contributing Institute: |
Physik der Medizinischen Bildgebung; INM-4 JARA-BRAIN; JARA-BRAIN |
Published in: | Behavioral and brain functions, 6 (2010) 1, S. 54 |
Imprint: |
London
BioMed Central
2010
|
DOI: |
10.1186/1744-9081-6-54 |
PubMed ID: |
20846375 |
Document Type: |
Journal Article |
Research Program: |
Imaging the Living Brain |
Link: |
OpenAccess OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://hdl.handle.net/2128/8722 in citations.
BackgroundAttention deficits belong to the main cognitive symptoms of schizophrenia and come along with altered neural activity in previously described cerebral networks. Given the high heritability of schizophrenia the question arises if impaired function of these networks is modulated by susceptibility genes and detectable in healthy risk allele carriers.MethodsThe present event-related fMRI study investigated the effect of the single nucleotide polymorphism (SNP) rs1018381 of the DTNBP1 (dystrobrevin-binding protein 1) gene on brain activity in 80 subjects while performing the attention network test (ANT). In this reaction time task three domains of attention are probed simultaneously: alerting, orienting and executive control of attention.ResultsRisk allele carriers showed impaired performance in the executive control condition associated with reduced neural activity in the left superior frontal gyrus [Brodmann area (BA) 9]. Risk allele carriers did not show alterations in the alerting and orienting networks.ConclusionsBA 9 is a key region of schizophrenia pathology and belongs to a network that has been shown previously to be involved in impaired executive control mechanisms in schizophrenia. Our results identified the impact of DTNBP1 on the development of a specific attention deficit via modulation of a left prefrontal network. |