This title appears in the Scientific Report :
2015
Please use the identifier:
http://dx.doi.org/10.1002/mrm.25086 in citations.
Analysis of proton-density bias corrections based on T 1 measurement for robust quantification of water content in the brain at 3 Tesla
Analysis of proton-density bias corrections based on T 1 measurement for robust quantification of water content in the brain at 3 Tesla
PurposeEstimating tissue water content using high field MRI, such as 3 Tesla (T), is challenging due to the difficulty in dissociating the radio frequency inhomogeneity pattern from the signal arising from tissue intrinsic proton density (PD) variations. To overcome this problem the longitudinal rel...
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Personal Name(s): | Abbas, Zaheer |
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Gras, Vincent / Möllenhoff, Klaus / Keil, Fabian / Oros-Peusquens, Ana-Maria / Shah, Nadim J. (Corresponding Author) | |
Contributing Institute: |
Physik der Medizinischen Bildgebung; INM-4 JARA-BRAIN; JARA-BRAIN |
Published in: | Magnetic resonance in medicine, 72 (2014) 6, S. 1735 - 1745 |
Imprint: |
New York, NY [u.a.]
Wiley-Liss
2014
|
DOI: |
10.1002/mrm.25086 |
Document Type: |
Journal Article |
Research Program: |
Imaging the Living Brain |
Publikationsportal JuSER |
PurposeEstimating tissue water content using high field MRI, such as 3 Tesla (T), is challenging due to the difficulty in dissociating the radio frequency inhomogeneity pattern from the signal arising from tissue intrinsic proton density (PD) variations. To overcome this problem the longitudinal relaxation time T1 can be combined with an initial guess of the PD to yield the desired PD bias correction. However, it is necessary to know whether T1 effects, i.e., any effect contributing to T1 while being independent of tissue hydration, influence the estimated correction.MethodsTwenty-five healthy subjects underwent a quantitative 3T MRI protocol enabling acquisition of 64 slices with 1 mm in-plane resolution and 2 mm slice thickness in 14 min. Influence of T1 effects on the estimated water content map is evaluated using a dedicated method including T1 and T2* information and region of interest-based water content values are compared with the literature.ResultsOur analysis indicates that the PD bias correction based on T1 is largely insensitive to T1 effects. Besides, water content results are in good agreement with literature values obtained at 1.5T.ConclusionThis study demonstrates the applicability of a PD bias correction based on T1 to yield tissue water content at 3T. |