This title appears in the Scientific Report :
2015
Please use the identifier:
http://hdl.handle.net/2128/8720 in citations.
Please use the identifier: http://dx.doi.org/10.1371/journal.pcbi.1003529 in citations.
Comparative Analysis of the Macroscale Structural Connectivity in the Macaque and Human Brain
Comparative Analysis of the Macroscale Structural Connectivity in the Macaque and Human Brain
The macaque brain serves as a model for the human brain, but its suitability is challenged by unique human features, including connectivity reconfigurations, which emerged during primate evolution. We perform a quantitative comparative analysis of the whole brain macroscale structural connectivity o...
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Personal Name(s): | Goulas, Alexandros (Corresponding Author) |
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Bastiani, Matteo / Bezgin, Gleb / Uylings, Harry B. M. / Roebroeck, Alard / Stiers, Peter | |
Contributing Institute: |
Physik der Medizinischen Bildgebung; INM-4 JARA-BRAIN; JARA-BRAIN |
Published in: | PLoS Computational Biology, 10 (2014) 3, S. e1003529 |
Imprint: |
San Francisco, Calif.
Public Library of Science
2014
|
PubMed ID: |
24676052 |
DOI: |
10.1371/journal.pcbi.1003529 |
Document Type: |
Journal Article |
Research Program: |
Imaging the Living Brain |
Link: |
OpenAccess OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.1371/journal.pcbi.1003529 in citations.
The macaque brain serves as a model for the human brain, but its suitability is challenged by unique human features, including connectivity reconfigurations, which emerged during primate evolution. We perform a quantitative comparative analysis of the whole brain macroscale structural connectivity of the two species. Our findings suggest that the human and macaque brain as a whole are similarly wired. A region-wise analysis reveals many interspecies similarities of connectivity patterns, but also lack thereof, primarily involving cingulate regions. We unravel a common structural backbone in both species involving a highly overlapping set of regions. This structural backbone, important for mediating information across the brain, seems to constitute a feature of the primate brain persevering evolution. Our findings illustrate novel evolutionary aspects at the macroscale connectivity level and offer a quantitative translational bridge between macaque and human research. |