Lights on and action! Controlling microbial gene expression by light
Lights on and action! Controlling microbial gene expression by light
Light-mediated control of gene expression and thus of any protein function and metabolic process in living microbes is a rapidly developing field of research in the areas of functional genomics, systems biology, and biotechnology. The unique physical properties of the environmental factor light allo...
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Personal Name(s): | Drepper, Thomas (Corresponding Author) |
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Krauss, Ulrich / Meyer zu Berstenhorst, Sonja / Pietruszka, Jörg / Jaeger, Karl-Erich | |
Contributing Institute: |
Institut für Bioorganische Chemie (HHUD); IBOC |
Published in: | Applied microbiology and biotechnology, 90 (2011) 1, S. 23 - 40 |
Imprint: |
Berlin
Springer
2011
|
PubMed ID: |
21336931 |
DOI: |
10.1007/s00253-011-3141-6 |
Document Type: |
Journal Article |
Research Program: |
ohne Topic |
Publikationsportal JuSER |
Light-mediated control of gene expression and thus of any protein function and metabolic process in living microbes is a rapidly developing field of research in the areas of functional genomics, systems biology, and biotechnology. The unique physical properties of the environmental factor light allow for an independent photocontrol of various microbial processes in a noninvasive and spatiotemporal fashion. This mini review describes recently developed strategies to generate photo-sensitive expression systems in bacteria and yeast. Naturally occurring and artificial photoswitches consisting of light-sensitive input domains derived from different photoreceptors and regulatory output domains are presented and individual properties of light-controlled expression systems are discussed. |