This title appears in the Scientific Report :
2015
Please use the identifier:
http://dx.doi.org/10.1002/anie.201502315 in citations.
Multi-Level Logic Gate Operation Based on Amplified Aptasensor Performance
Multi-Level Logic Gate Operation Based on Amplified Aptasensor Performance
Conventional electronic circuits can perform multi-level logic operations; however, this capability is rarely realized by biological logic gates. In addition, the question of how to close the gap between biomolecular computation and silicon-based electrical circuitry is still a key issue in the bioe...
Saved in:
Personal Name(s): | Feng, Lingyan |
---|---|
Lyu, Zhaozi / Offenhäusser, Andreas / Mayer, Dirk (Corresponding Author) | |
Contributing Institute: |
JARA-FIT; JARA-FIT Bioelektronik; PGI-8 |
Published in: | Angewandte Chemie / International edition, 54 (2015) 26, S. 7693 - 7697 |
Imprint: |
Weinheim
Wiley-VCH
2015
|
PubMed ID: |
25959438 |
DOI: |
10.1002/anie.201502315 |
Document Type: |
Journal Article |
Research Program: |
Controlling Configuration-Based Phenomena |
Publikationsportal JuSER |
Conventional electronic circuits can perform multi-level logic operations; however, this capability is rarely realized by biological logic gates. In addition, the question of how to close the gap between biomolecular computation and silicon-based electrical circuitry is still a key issue in the bioelectronics field. Here we explore a novel split aptamer-based multi-level logic gate built from INHIBIT and AND gates that performs a net XOR analysis, with electrochemical signal as output. Based on the aptamer–target interaction and a novel concept of electrochemical rectification, a relayed charge transfer occurs upon target binding between aptamer-linked redox probes and solution-phase probes, which amplifies the sensor signal and facilitates a straightforward and reliable diagnosis. This work reveals a new route for the design of bioelectronic logic circuits that can realize multi-level logic operation, which has the potential to simplify an otherwise complex diagnosis to a “yes” or “no” decision. |