This title appears in the Scientific Report :
2012
Please use the identifier:
http://dx.doi.org/10.1016/j.neuroimage.2012.03.027 in citations.
One-year test-retest reliability of intrinsic connectivity network fMRI in older adults
One-year test-retest reliability of intrinsic connectivity network fMRI in older adults
"Resting-state" or task-free fMRI can assess intrinsic connectivity network (ICN) integrity in health and disease, suggesting a potential for use of these methods as disease-monitoring biomarkers. Numerous analytical options are available, including model-driven ROI-based correlation analy...
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Personal Name(s): | Guo, C.C. |
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Kurth, F. / Zhou, J. / Mayer, E.A. / Eickhoff, S.B. / Kramer, J.H. / Seeley, W.W. | |
Contributing Institute: |
Strukturelle und funktionelle Organisation des Gehirns; INM-1 |
Published in: | NeuroImage, 61 (2012) S. 1471 - 1483 |
Imprint: |
Orlando, Fla.
Academic Press
2012
|
Physical Description: |
1471 - 1483 |
PubMed ID: |
22446491 |
DOI: |
10.1016/j.neuroimage.2012.03.027 |
Document Type: |
Journal Article |
Research Program: |
Connectivity and Activity Funktion und Dysfunktion des Nervensystems |
Series Title: |
NeuroImage
61 |
Subject (ZB): | |
Publikationsportal JuSER |
"Resting-state" or task-free fMRI can assess intrinsic connectivity network (ICN) integrity in health and disease, suggesting a potential for use of these methods as disease-monitoring biomarkers. Numerous analytical options are available, including model-driven ROI-based correlation analysis and model-free, independent component analysis (ICA). High test-retest reliability will be a necessary feature of a successful ICN biomarker, yet available reliability data remains limited. Here, we examined ICN fMRI test-retest reliability in 24 healthy older subjects scanned roughly one year apart. We focused on the salience network, a disease-relevant ICN not previously subjected to reliability analysis, as well as the default mode network. Most ICN analytical methods proved reliable (intraclass coefficients>0.4) and were further improved by wavelet analysis. Seed-based ROI correlation analysis showed high scan-wise reliability, whereas graph theoretical analysis and temporal concatenation group ICA proved most reliable at the individual unit-wise level (voxels, ROIs). Including global signal regression in ROI-based correlation analyses reduced reliability. Our study provides a direct comparison between the most commonly used ICN fMRI methods and potential guidelines for measuring intrinsic connectivity in aging control and patient populations over time. |