This title appears in the Scientific Report :
2013
Please use the identifier:
http://dx.doi.org/10.1159/000339528 in citations.
Consistent neurodegeneration and its association with clinical progression in Huntington's Disease: A coordinated-based meta-analysis
Consistent neurodegeneration and its association with clinical progression in Huntington's Disease: A coordinated-based meta-analysis
Background: The neuropathological hallmark of Huntington's disease (HD) is progressive striatal loss starting several years prior to clinical onset. In the past decade, whole-brain magnetic resonance imaging (MRI) studies have provided accumulating evidence for widely distributed cortical and s...
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Personal Name(s): | Dogan, I. |
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Eickhoff, S.B. / Schulz, J.B. / Shah, N.J. / Laird, A.R. / Fox, P.T. / Reetz, K. | |
Contributing Institute: |
Strukturelle und funktionelle Organisation des Gehirns; INM-1 Physik der Medizinischen Bildgebung; INM-4 |
Published in: | Neurodegenerative diseases, 1 (2013) S. 23-35 |
Imprint: |
Basel
Karger
2013
|
Physical Description: |
00 |
PubMed ID: |
22922585 |
DOI: |
10.1159/000339528 |
Document Type: |
Journal Article |
Research Program: |
GRK 1328: Gehirn und Verhalten: Neurobiologische Grundlagen von Emotion und sozialer Kognition bei Schizophrenie und Autismus Helmholtz Alliance on Systems Biology Funktion und Dysfunktion des Nervensystems |
Series Title: |
Neurodegenerative Diseases
00 |
Publikationsportal JuSER |
Background: The neuropathological hallmark of Huntington's disease (HD) is progressive striatal loss starting several years prior to clinical onset. In the past decade, whole-brain magnetic resonance imaging (MRI) studies have provided accumulating evidence for widely distributed cortical and subcortical atrophy in the early course of the disease. Objective: In order to synthesize current morphometric MRI findings and to investigate the impact of clinical and genetic features on structural changes, we performed a coordinate-based meta-analysis of voxel-based morphometry (VBM) studies in HD. Methods: Twenty HD samples derived from 17 studies were integrated in the analysis comparing a total of 685 HD mutation carriers [345 presymptomatic (pre-HD) and 340 symptomatic (symp-HD) subjects] and 507 controls. Convergent findings across studies were delineated using the anatomical likelihood estimation approach. Effects of genetic and clinical parameters on the likelihood of observing VBM findings were calculated by means of correlation analyses. Results: Pre-HD studies featured convergent evidence for neurodegeneration in the basal ganglia, amygdala, thalamus, insula and occipital regions. In symp-HD, cerebral atrophy was more pronounced and spread to cortical regions (i.e. inferior frontal, premotor, sensorimotor, midcingulate, frontoparietal and temporoparietal cortices). Higher cytosine-adenosine-guanosine repeats were associated with striatal degeneration, while parameters of disease progression and motor impairment additionally correlated with cortical atrophy, especially in sensorimotor areas. Conclusion: This first quantitative meta-analysis in HD demonstrates the extent of striatal atrophy and further consistent extrastriatal degeneration before clinical conversion. Sensorimotor areas seem to be core regions affected in symp-HD and, along with widespread cortical atrophy, may account for the clinical heterogeneity in HD. |