This title appears in the Scientific Report :
2012
Please use the identifier:
http://dx.doi.org/10.1053/j.semnuclmed.2012.06.001 in citations.
Brain tumors
Brain tumors
This review addresses the specific contributions of nuclear medicine techniques, and especially positron emission tomography (PET), for diagnosis and management of brain tumors. (18)F-Fluorodeoxyglucose PET has particular strengths in predicting prognosis and differentiating cerebral lymphoma from n...
Saved in:
Personal Name(s): | Herholz, K. |
---|---|
Langen, K.J. / Schiepers, C. / Mountz, J.M. | |
Contributing Institute: |
Physik der Medizinischen Bildgebung; INM-4 |
Published in: | Seminars in nuclear medicine, 42 (2012) S. 356 - 370 |
Imprint: |
New York, NY
[u.a.] : Elsevier
2012
|
Physical Description: |
356 - 370 |
DOI: |
10.1053/j.semnuclmed.2012.06.001 |
PubMed ID: |
23026359 |
Document Type: |
Journal Article |
Research Program: |
Neuroimaging Funktion und Dysfunktion des Nervensystems |
Series Title: |
Seminars in Nuclear Medicine
42 |
Publikationsportal JuSER |
This review addresses the specific contributions of nuclear medicine techniques, and especially positron emission tomography (PET), for diagnosis and management of brain tumors. (18)F-Fluorodeoxyglucose PET has particular strengths in predicting prognosis and differentiating cerebral lymphoma from nonmalignant lesions. Amino acid tracers including (11)C-methionine, (18)F-fluoroethyltyrosine, and (18)F-l-3,4-dihydroxyphenylalanine provide high sensitivity, which is most useful for detecting recurrent or residual gliomas, including most low-grade gliomas. They also play an increasing role for planning and monitoring of therapy. (18)F-fluorothymidine can only be used in tumors with absent or broken blood-brain barrier and has potential for tumor grading and monitoring of therapy. Ligands for somatostatin receptors are of particular interest in pituitary adenomas and meningiomas. Tracers to image neovascularization, hypoxia, and phospholipid synthesis are under investigation for potential clinical use. All methods provide the maximum of information when used with image registration and fusion display with contrast-enhanced magnetic resonance imaging scans. Integration of PET and magnetic resonance imaging with stereotactic neuronavigation systems allows the targeting of stereotactic biopsies to obtain a more accurate histologic diagnosis and better planning of conformal and stereotactic radiotherapy. |