This title appears in the Scientific Report :
2016
Please use the identifier:
http://dx.doi.org/10.1097/RLI.0000000000000237 in citations.
Quantitative, organ-specific inter- and intra-scanner variability for 3 Tesla whole-body magnetic resonance imaging in a multi-centre, multi vendor study
Quantitative, organ-specific inter- and intra-scanner variability for 3 Tesla whole-body magnetic resonance imaging in a multi-centre, multi vendor study
INTRODUCTION: Whole-body magnetic resonance (MR) imaging is increasingly implemented in population-based cohorts and clinical settings. However, to quantify the variability introduced by the different scanners is essential to make conclusions about clinical and biological data, and relevant for inte...
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Personal Name(s): | Schlett, C. L. |
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Hendel, T. / Hirsch, J. G. / Weckbach, S. / Caspers, S. / Schulz-Menger, J. / Ittermann, T. / von Knobelsdorff, F. / Ladd, S. C. / Moebus, S. / Stroszczynski, C. / Fischer, B. / Leitzmann, M. / Kuhl, C. / Pessler, F. / Kemmling, Y. / Hetterich, H. / Amunts, K. / Günther, M. / Wacker, F. / Rummeny, E. / Kauczor, H. U. / Forsting, M. / Völzke, H. / Hosten, N. / Reiser, M. F. / Bamberg, F. | |
Contributing Institute: |
Strukturelle und funktionelle Organisation des Gehirns; INM-1 |
Published in: | Investigative radiology, 51 (2016) 4, S. 255-265 |
Imprint: |
Philadelphia, Pa.
Lippincott Williams & Wilkins
2016
|
DOI: |
10.1097/RLI.0000000000000237 |
PubMed ID: |
26646309 |
Document Type: |
Journal Article |
Research Program: |
Connectivity and Activity |
Publikationsportal JuSER |
INTRODUCTION: Whole-body magnetic resonance (MR) imaging is increasingly implemented in population-based cohorts and clinical settings. However, to quantify the variability introduced by the different scanners is essential to make conclusions about clinical and biological data, and relevant for internal/external validity. Thus, we determined the interscanner and intrascanner variability of different 3 T MR scanners for whole-body imaging. METHODS: Thirty volunteers were enrolled to undergo multicentric, interscanner as well intrascanner imaging as part of the German National Cohort pilot studies. A comprehensive whole-body MR protocol was installed at 9 sites including 7 different MR scanner models by all 4 major vendors. A set of quantitative, organ-specific measures (n = 20; eg, volume of brain's gray/white matter, pulmonary trunk diameter, vertebral body height) were obtained in blinded fashion. Reproducibility was determined using mean weighted relative differences and intraclass correlation coefficients. RESULTS: All participants (44 +/- 14 years, 50% female) successfully completed the imaging protocol except for two because of technical issues. Mean scan time was 2 hours and 32 minutes and differed significantly across scanners (range, 1 hour 59 minutes to 3 hours 12 minutes). A higher reproducibility of obtained measurements was observed for intrascanner than for interscanner comparisons (intraclass correlation coefficients, 0.80 +/- 0.17 vs 0.60 +/- 0.31, P = 0.005, respectively). In the interscanner comparison, mean relative difference ranged from 1.0% to 53.2%. Conversely, in the intrascanner comparison, mean relative difference ranged from 0.1% to 15.6%. There were no statistical differences for intrascanner and interscanner reproducibility between the different organ foci (all P >/= 0.24). CONCLUSIONS: While whole-body MR imaging-derived, organ-specific parameters are generally associated with good to excellent reproducibility, smaller differences are obtained when using identical MR scanner models by a single vendor. |