This title appears in the Scientific Report : 2015 

Acoustic Coordinated Reset Neuromodulation in a Real Life Patient Population with Chronic Tonal Tinnitus
Hauptmann, Christian (Corresponding author)
Ströbel, Armin / Williams, Mark / Patel, Nitesh / Wurzer, Hannes / von Stackelberg, Tatjana / Brinkmann, Uwe / Langguth, Berthold / Tass, Peter A.
Gehirn & Verhalten; INM-7
BioMed research international, 2015 (2015) S. 569052
New York [u.a.] Hindawi 2015
10.1155/2015/569052
26568958
Journal Article
Zusammenarbeits- und Lizenzoptionsvereinbarung zwischen Brook Henderson Group Limited und Forschungszentrum Jülich GmbH
(Dys-)function and Plasticity
OpenAccess
OpenAccess
Please use the identifier: http://dx.doi.org/10.1155/2015/569052 in citations.
Please use the identifier: http://hdl.handle.net/2128/9799 in citations.
Purpose. Primary tinnitus has a severe negative influence on the quality of life of a significant portion of the general population. Acoustic coordinated reset neuromodulation is designed to induce a long-lasting reduction of tinnitus symptoms. To test acoustic coordinated reset neuromodulation as a treatment for chronic, tonal tinnitus under real life conditions, an outpatient study “RESET Real Life” was commissioned by ANM GmbH. Herein we present the results of this study. Methods. In a prospective, open-label, nonrandomized, noncontrolled multicenter clinical study with 200 chronic tinnitus patients, tinnitus questionnaire TBF-12 and Global Clinical Improvement-Impression Scale (CGI-I7) are used to study the safety and efficacy of acoustic coordinated reset neuromodulation. 189 patients completed the last 12-month visit, 11 patients dropped out (8 because of nontreatment related reasons; 2 because tinnitus did not change; and 1 because tinnitus got louder). Results. Acoustic coordinated reset neuromodulation caused a statistically and clinically significant decrease in TBF-12 scores as well as in CGI-I7 after 12 months of therapy under real life conditions. There were no persistent adverse events reported that were related to the therapy. Conclusion. The field study “RESET Real Life” provides evidence for safety and efficacy of acoustic coordinated reset neuromodulation in a prospective, open-label, real life setting.