This title appears in the Scientific Report :
2016
Please use the identifier:
http://dx.doi.org/10.1093/schbul/sbw015 in citations.
Differential Patterns of Dysconnectivity in Mirror Neuron and Mentalizing Networks in Schizophrenia.
Differential Patterns of Dysconnectivity in Mirror Neuron and Mentalizing Networks in Schizophrenia.
Impairments of social cognition are well documented in patients with schizophrenia (SCZ), but the neural basis remains poorly understood. In light of evidence that suggests that the 'mirror neuron system' (MNS) and the 'mentalizing network' (MENT) are key substrates of intersubje...
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Personal Name(s): | Schilbach, Leonhard |
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Derntl, Birgit (Corresponding author) / Aleman, Andre / Caspers, Svenja / Clos, Mareike / Diederen, Kelly M J / Gruber, Oliver / Kogler, Lydia / Liemburg, Edith J / Sommer, Iris E / Müller, Veronika / Cieslik, Edna / Eickhoff, Simon | |
Contributing Institute: |
Strukturelle und funktionelle Organisation des Gehirns; INM-1 JARA-BRAIN; JARA-BRAIN |
Published in: | Schizophrenia bulletin, 42 (2016) 5, S. 1135-1148 |
Imprint: |
Oxford
Oxford Univ. Press
2016
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PubMed ID: |
26940699 |
DOI: |
10.1093/schbul/sbw015 |
Document Type: |
Journal Article |
Research Program: |
Supercomputing and Modelling for the Human Brain The Human Brain Project Connectivity and Activity |
Publikationsportal JuSER |
Impairments of social cognition are well documented in patients with schizophrenia (SCZ), but the neural basis remains poorly understood. In light of evidence that suggests that the 'mirror neuron system' (MNS) and the 'mentalizing network' (MENT) are key substrates of intersubjectivity and joint action, it has been suggested that dysfunction of these neural networks may underlie social difficulties in SCZ patients. Additionally, MNS and MENT might be associated differently with positive vs negative symptoms, given prior social cognitive and symptom associations. We assessed resting state functional connectivity (RSFC) in meta-analytically defined MNS and MENT networks in this patient group. Magnetic resonance imaging (MRI) scans were obtained from 116 patients and 133 age-, gender- and movement-matched healthy controls (HC) at 5 different MRI sites. Network connectivity was analyzed for group differences and correlations with clinical symptoms. Results demonstrated decreased connectivity within the MNS and also the MENT in patients compared to controls. Notably, dysconnectivity of the MNS was related to symptom severity, while no such relationship was observed for the MENT. In sum, these findings demonstrate that differential patterns of dysconnectivity exist in SCZ patients, which may contribute differently to the interpersonal difficulties commonly observed in the disorder. |