This title appears in the Scientific Report :
2004
Please use the identifier:
http://dx.doi.org/10.1016/j.nucmedbio.2003.10.007 in citations.
Binding of tritiated and radioiodinated Zm241,385 to brain A2A adenosine receptors
Binding of tritiated and radioiodinated Zm241,385 to brain A2A adenosine receptors
Autoradiography on rat brain using tritiated (1*), mono- (2*) and di-radioiodinated (3*) derivatives of the A(2A) adenosine receptor antagonist ZM241,385 showed high receptor density in striatum. K(D)s of 1*, 2* and 3* were 0.4, 2.2 and 15 nM and nonspecific binding was 5, 40 and 50% of total bindin...
Saved in:
Personal Name(s): | Sihver, W. |
---|---|
Bier, D. / Holschbach, M. H. / Schulze, A. / Wutz, W. / Olsson, R. A. / Coenen, H. H. | |
Contributing Institute: |
Institut für Nuklearchemie; INC |
Published in: | Nuclear medicine and biology, 31 (2004) S. 173 - 177 |
Imprint: |
Amsterdam [u.a.]
Elsevier
2004
|
Physical Description: |
173 - 177 |
DOI: |
10.1016/j.nucmedbio.2003.10.007 |
PubMed ID: |
15013482 |
Document Type: |
Journal Article |
Research Program: |
Neurowissenschaften |
Series Title: |
Nuclear Medicine and Biology
31 |
Subject (ZB): | |
Publikationsportal JuSER |
Autoradiography on rat brain using tritiated (1*), mono- (2*) and di-radioiodinated (3*) derivatives of the A(2A) adenosine receptor antagonist ZM241,385 showed high receptor density in striatum. K(D)s of 1*, 2* and 3* were 0.4, 2.2 and 15 nM and nonspecific binding was 5, 40 and 50% of total binding. Striatal uptake of 2* in mice was approximately 0.2% ID/g 60 min post-injection; blocking by 2 was insignificant. Poor penetration of the blood brain barrier and high nonspecific binding make 2* unsuitable for imaging striatal receptors. |