This title appears in the Scientific Report :
2003
Please use the identifier:
http://dx.doi.org/10.1016/S0168-1656(03)00154-8 in citations.
The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins
The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins
The complete genomic sequence of Corynebacterium glutainicum ATCC 13032, well-known in industry for the production of amino acids, e.g. of L-glutamate and L-lysine was determined. The C glutamician genome was found to consist of a single circular chromosome comprising 3 282 708 base pairs. Several D...
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Personal Name(s): | Kalinowski, J. |
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Bathe, B. / Bischoff, N. / Bott, M. / Burkovski, A. / Dusch, N. / Eggeling, L. / Eikmanns, B. / Gaigalat, A. V. / Goesmann, A. / Hartmann, M. / Huthmacher, K. / Krämer, R. / Linke, B. / McHardy, A. C. / Meyer, F. / Möckel, M. / Pfefferle, W. / Pühler, A. / Rey, D. / Rückert, C. / Sahm, H. / Wendisch, V. F. / Wiegräbe, I. / Tauch, A. | |
Contributing Institute: |
Biotechnologie 1; IBT-1 |
Published in: | Journal of biotechnology, 104 (2003) S. 5 - 25 |
Imprint: |
Amsterdam [u.a.]
Elsevier Science
2003
|
Physical Description: |
5 - 25 |
PubMed ID: |
12948626 |
DOI: |
10.1016/S0168-1656(03)00154-8 |
Document Type: |
Journal Article |
Research Program: |
Biotechnologie |
Series Title: |
Journal of Biotechnology
104 |
Subject (ZB): | |
Publikationsportal JuSER |
The complete genomic sequence of Corynebacterium glutainicum ATCC 13032, well-known in industry for the production of amino acids, e.g. of L-glutamate and L-lysine was determined. The C glutamician genome was found to consist of a single circular chromosome comprising 3 282 708 base pairs. Several DNA regions of unusual composition were identified that were potentially acquired by horizontal gene transfer, e.g. a segment of DNA from C diphtheriae and a prophage-containing region. After automated and manual annotation, 3002 protein-coding genes have been identified, and to 2489 of these, functions were assigned by homologies to known proteins. These analyses confirm the taxonomic position of C glutamicum as related to Mycobacteria and show a broad metabolic diversity as expected for a bacterium living in the soil. As an example for biotechnological application the complete genome sequence was used to reconstruct the metabolic flow of carbon into a number of industrially important products derived from the amino acid L-aspartate. (C) 2003 Elsevier B.V. All rights reserved. |