This title appears in the Scientific Report :
2008
Please use the identifier:
http://dx.doi.org/10.1007/s10867-008-9119-7 in citations.
On the Problem of Diffusivity in Heterogenous Biological Materials with Random Structure
On the Problem of Diffusivity in Heterogenous Biological Materials with Random Structure
Biological tissues are multicompartmental heterogeneous media composed of cellular and subcellular domains. Randomly walking water molecules may have different diffusion coefficients and densities (concentrations) in different domains, namely within cells and within the outer medium. Results of the...
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Personal Name(s): | Posnansky, O.P. |
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Shah, J. N. | |
Contributing Institute: |
Institut für Neurowissenschaften und Biophysik - Medizin; INB-3 |
Published in: | Journal of biological physics, 34 (2008) S. 551 - 567 |
Imprint: |
Dordrecht [u.a.]
Springer Science + Business Media B.V
2008
|
Physical Description: |
551 - 567 |
DOI: |
10.1007/s10867-008-9119-7 |
PubMed ID: |
19669513 |
Document Type: |
Journal Article |
Research Program: |
Funktion und Dysfunktion des Nervensystems |
Series Title: |
Journal of Biological Physics
34 |
Subject (ZB): | |
Publikationsportal JuSER |
Biological tissues are multicompartmental heterogeneous media composed of cellular and subcellular domains. Randomly walking water molecules may have different diffusion coefficients and densities (concentrations) in different domains, namely within cells and within the outer medium. Results of the proposed effective media scale-averaging iterative scheme are used to explore the effects of a large range of microstructural and compositional parameters on the apparent (effective) diffusion coefficient. A self-consistent modelling framework for predicting the steady-state effective diffusion coefficient is presented; the framework reveals the strong dependence of the apparent diffusion coefficient on the ratio of the microscopic diffusion coefficients of the comprising phases, permeability of the cells, and their volume fractions. |